Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA.
Curr Opin Pharmacol. 2010 Oct;10(5):588-93. doi: 10.1016/j.coph.2010.05.008. Epub 2010 Jun 8.
Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating lipolysis in adipose tissue and fatty acid oxidation. Brown adipocyte development within white adipose tissue of humans suggests that mouse models may be applicable to human obesity. Consequently, new therapies should target adipose tissue to specifically reduce fat mass through controlled triglyceride utilization.
肥胖是一种慢性疾病，会增加患各种疾病的风险，特别是心血管功能障碍、2 型糖尿病和某些类型的癌症。在这篇综述中，我们强调了最近在小鼠模型中获得的证据，这些证据支持通过刺激脂肪组织中的脂肪分解和脂肪酸氧化来增加脂肪脂质利用的潜在益处。人类白色脂肪组织中棕色脂肪细胞的发育表明，小鼠模型可能适用于人类肥胖。因此，新的治疗方法应该针对脂肪组织，通过控制甘油三酯的利用来特异性地减少脂肪量。
