School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada.
Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2826-32. doi: 10.1158/1055-9965.EPI-10-0521. Epub 2010 Sep 22.
Aerobic exercise training (AET) is known to increase RBC production; however, this has not been evaluated in breast cancer patients undergoing adjuvant chemotherapy. The purpose of this study was to examine the changes in hemoglobin (Hb) levels in the Supervised Trial of Aerobic versus Resistance Training (START) and to determine its association with changes in VO(2peak).
Two hundred and forty-two breast cancer patients initiating chemotherapy were randomized to usual care (n = 82), resistance exercise (RET, n = 82), or AET (n = 78) groups for the duration of their chemotherapy (median, 17 weeks). Supervised exercise was thrice weekly based on standard AET and RET prescriptions. Aerobic fitness (VO(2peak)) and Hb concentration were measured at baseline and end of chemotherapy.
Regardless of the exercise group, Hb declined over the course of chemotherapy (13.4 ± 10.0 to 11.8 ± 11.5 g/dL, P < 0.01). Both AET and RET groups had significant, moderate correlations between the change in VO(2peak) and Hb (AET: r = 0.49, P < 0.001; RET: r = 0.39, P = 0.001).
The results indicate that regular exercise does not protect against the decline in Hb associated with chemotherapy in breast cancer patients, but resulted in a stronger association between Hb and VO(2peak).
Even with the chemotherapy-induced decline in Hb, breast cancer patients can maintain their aerobic capacity by participating in regular aerobic exercise. Further studies are required to determine safe intensity levels that may stimulate the maintenance of Hb levels in breast cancer patients.
有氧运动训练（AET）已知可增加红细胞生成；然而，这尚未在接受辅助化疗的乳腺癌患者中进行评估。本研究的目的是检查有氧运动与阻力训练（START）中血红蛋白（Hb）水平的变化，并确定其与 VO₂peak 变化的关系。
242 名开始接受化疗的乳腺癌患者随机分为常规护理组（n = 82）、阻力运动组（RET，n = 82）或有氧运动组（AET，n = 78），持续接受化疗（中位数，17 周）。基于标准 AET 和 RET 处方，每周进行三次监督运动。在化疗结束时测量有氧健身（VO₂peak）和 Hb 浓度。
无论运动组如何，Hb 在化疗过程中下降（13.4 ± 10.0 至 11.8 ± 11.5 g/dL，P < 0.01）。AET 和 RET 组 VO₂peak 和 Hb 变化之间均存在显著的中度相关性（AET：r = 0.49，P < 0.001；RET：r = 0.39，P = 0.001）。
结果表明，定期运动不能防止与化疗相关的 Hb 下降，但会导致 Hb 和 VO₂peak 之间的相关性更强。
即使 Hb 因化疗而下降，乳腺癌患者仍可以通过定期进行有氧运动来保持其有氧能力。需要进一步研究以确定可能刺激乳腺癌患者 Hb 水平维持的安全强度水平。
