Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Nat Rev Mol Cell Biol. 2010 Oct;11(10):715-27. doi: 10.1038/nrm2972.
Metabolic activity is a crucial determinant of a cell's decision to proliferate or die. Although it is not fully understood how metabolic pathways such as glycolysis and the pentose phosphate pathway communicate to cell cycle and apoptotic effectors, it is clear that a complex network of signalling molecules is required to integrate metabolic inputs. D-type cyclins, cyclin-dependent kinases, the anaphase-promoting complex, p53, caspase 2 and B cell lymphoma 2 proteins, among others, have been shown to be regulated by metabolic crosstalk. Elucidating these pathways is of great importance, as metabolic aberrations and their downstream effects are known to contribute to the aetiology of cancer and degenerative disorders.
代谢活性是决定细胞增殖或死亡的关键因素。尽管目前还不完全清楚糖酵解和磷酸戊糖途径等代谢途径如何与细胞周期和凋亡效应器进行通讯，但显然需要一个复杂的信号分子网络来整合代谢输入。已经表明，D 型细胞周期蛋白、细胞周期蛋白依赖性激酶、后期促进复合物、p53、半胱天冬酶 2 和 B 细胞淋巴瘤 2 蛋白等受到代谢串扰的调节。阐明这些途径非常重要，因为代谢异常及其下游效应已知会导致癌症和退行性疾病的发病机制。
