Woeller Collynn F, Woodroof Aubrey, Lacy Shannon H, Cottler Patrick S, Gui Jane L, Piñeros-Fernandez Angela, Pollock Stephen J, Phipps Richard P
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY.
PermeaDerm, Inc, Carlsbad, Calif.
Eplasty. 2018 May 24;18:e20. eCollection 2018.
New treatments that promote wound healing while preventing scar formation are needed. One option in topical wound healing is the use of temporary dressings that allow the natural healing process with minimal scar formation. We evaluated the temporary wound dressings PermeaDerm C, and a PermeaDerm C derivative coated with the anti-scarring agent, salinomycin (PermeaDerm D) in a pig model of wound healing to show the efficacy of these wound dressings in vivo. Porcine fibroblasts grow well in the presence of PermeaDerm C or PermeaDerm A, and salinomycin reduces excessive myofibroblast formation in porcine fibroblasts in vitro. In vivo, wounds treated with PermeaDerm C and PermeaDerm A did not show abnormal or unwanted healing patterns up to 8 weeks post-wound formation. Wounds covered with either PermeaDerm C or PermeaDerm A showed a more mature wound-healing phenotype than the control wounds. PermeaDerm C and PermeaDerm A allowed wound healing, revealing the potential of both PermeaDerm C and PermeaDerm A to promote effective healing while preventing excessive scar formation.
需要有既能促进伤口愈合又能防止瘢痕形成的新疗法。局部伤口愈合的一种选择是使用临时敷料，使自然愈合过程在瘢痕形成最少的情况下进行。我们在猪伤口愈合模型中评估了临时伤口敷料PermeaDerm C以及涂有抗瘢痕剂盐霉素的PermeaDerm C衍生物（PermeaDerm D），以证明这些伤口敷料在体内的疗效。猪成纤维细胞在PermeaDerm C或PermeaDerm A存在的情况下生长良好，并且盐霉素在体外可减少猪成纤维细胞中过度的肌成纤维细胞形成。在体内，用PermeaDerm C和PermeaDerm A处理的伤口在伤口形成后8周内未显示出异常或不良的愈合模式。覆盖有PermeaDerm C或PermeaDerm A的伤口比对照伤口表现出更成熟的伤口愈合表型。PermeaDerm C和PermeaDerm A可实现伤口愈合，揭示了PermeaDerm C和PermeaDerm A在促进有效愈合同时防止过度瘢痕形成方面的潜力。
