Dreifke Michael B, Jayasuriya Amil A, Jayasuriya Ambalangodage C
Department of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH 43614-5807, USA.
Undergraduate Program, Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:651-62. doi: 10.1016/j.msec.2014.12.068. Epub 2014 Dec 19.
In this review, we describe current and future potential wound healing treatments for acute and chronic wounds. The current wound healing approaches are based on autografts, allografts, and cultured epithelial autografts, and wound dressings based on biocompatible and biodegradable polymers. The Food and Drug Administration approved wound healing dressings based on several polymers including collagen, silicon, chitosan, and hyaluronic acid. The new potential therapeutic intervention for wound healing includes sustained delivery of growth factors, and siRNA delivery, targeting microRNA, and stem cell therapy. In addition, environment sensors can also potentially utilize to monitor and manage microenvironment at wound site. Sensors use optical, odor, pH, and hydration sensors to detect such characteristics as uric acid level, pH, protease level, and infection - all in the hopes of early detection of complications.
在本综述中,我们描述了用于急性和慢性伤口的当前及未来潜在的伤口愈合治疗方法。当前的伤口愈合方法基于自体移植、异体移植和培养的上皮自体移植,以及基于生物相容性和可生物降解聚合物的伤口敷料。美国食品药品监督管理局批准了基于多种聚合物(包括胶原蛋白、硅、壳聚糖和透明质酸)的伤口愈合敷料。伤口愈合的新潜在治疗干预措施包括生长因子的持续递送、靶向微小RNA的小干扰RNA递送和干细胞疗法。此外,环境传感器也可潜在地用于监测和管理伤口部位的微环境。传感器使用光学、气味、pH和水合传感器来检测尿酸水平、pH、蛋白酶水平和感染等特征,所有这些都是为了早期发现并发症。