水中的内分泌干扰物及其对生殖系统的影响。
Endocrine Disruptors in Water and Their Effects on the Reproductive System.
机构信息
Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
出版信息
Int J Mol Sci. 2020 Mar 12;21(6):1929. doi: 10.3390/ijms21061929.
Abstract
Anthropogenic contaminants in water can impose risks to reproductive health. Most of these compounds are known to be endocrine disrupting chemicals (EDCs). EDCs can impact the endocrine system and subsequently impair the development and fertility of non-human animals and humans. The source of chemical contamination in water is diverse, originating from byproducts formed during water disinfection processes, release from industry and livestock activity, or therapeutic drugs released into sewage. This review discusses the occurrence of EDCs in water such as disinfection byproducts, fluorinated compounds, bisphenol A, phthalates, pesticides, and estrogens, and it outlines their adverse reproductive effects in non-human animals and humans.
摘要
人为污染物会对生殖健康造成威胁。这些化合物大多是已知的内分泌干扰化学物质（EDCs）。EDCs 会影响内分泌系统，从而损害非人类动物和人类的发育和生育能力。水中化学污染物的来源多种多样，包括水消毒过程中形成的副产物、工业和畜牧业活动释放的物质，以及排放到污水中的治疗药物等。本综述讨论了水中 EDCs 的存在情况，如消毒副产物、含氟化合物、双酚 A、邻苯二甲酸酯、农药和雌激素，并概述了它们对非人类动物和人类的不良生殖影响。
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Chemosphere. 2020 Mar;242:125208. doi: 10.1016/j.chemosphere.2019.125208. Epub 2019 Oct 24.
2
Phthalate Esters and Their Potential Risk in PET Bottled Water Stored under Common Conditions.邻苯二甲酸酯及其在常见条件下储存的 PET 瓶装水中的潜在风险。
Int J Environ Res Public Health. 2019 Dec 24;17(1):141. doi: 10.3390/ijerph17010141.
3
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Environ Int. 2020 Feb;135:105342. doi: 10.1016/j.envint.2019.105342. Epub 2019 Dec 18.
4
Perfluoro-octanoic acid impairs sperm motility through the alteration of plasma membrane.全氟辛酸通过改变质膜来损害精子活力。
J Endocrinol Invest. 2020 May;43(5):641-652. doi: 10.1007/s40618-019-01152-0. Epub 2019 Nov 27.
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6
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7
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9
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