Genetic epidemiology: successes and challenges of genome-wide association studies using the example of age-related macular degeneration.
作者信息
Peter Inga, Seddon Johanna M
机构信息
Department of Genetics and Genomic Sciences, Mount SinaiSchool of Medicine, New York, New York, USA.
出版信息
Am J Ophthalmol. 2010 Oct;150(4):450-452.e2. doi: 10.1016/j.ajo.2010.06.012.
Abstract
摘要
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3
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4
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5
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6
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8
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