University of Missouri, Comparative Orthopaedic Laboratory, 900 East Campus Drive, Columbia, MO 65211, USA.
Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S66-79. doi: 10.1016/j.joca.2010.04.017.
The dog is a common model for study of osteoarthritis (OA). Subjective histologic scoring systems have often served as the reference standard for presence and severity of OA. However, these scoring systems have perceived shortcomings. The system developed for this report attempts to address these shortcomings by providing a standardized methodology for global assessment of the joint, versatility and the potential for relative weighting of pathology, allowing for comparison among time points, studies, and centers, and critical analysis of the system's reliability. The proposed system for assessment of canine tissues appears to provide an effective method for global assessment of articular pathology in OA. The system is versatile, comprehensive, and reliable and appears to have advantages over conventional scoring systems.
狗是研究骨关节炎（OA）的常用模型。主观组织学评分系统通常作为 OA 存在和严重程度的参考标准。然而，这些评分系统存在一些缺点。本报告中开发的系统试图通过提供一种标准化的方法来解决这些缺点，对关节进行全面评估，具有多功能性和对病理学进行相对加权的潜力，从而能够在不同时间点、研究和中心之间进行比较，并对系统的可靠性进行批判性分析。提出的用于评估犬组织的系统似乎为 OA 中关节病理的全面评估提供了一种有效的方法。该系统具有多功能性、全面性和可靠性，并且似乎比传统的评分系统具有优势。
