前列腺素 E2 和血管内皮生长因子对精子的影响可能导致子宫内膜异位症相关的不孕。
Effects of prostaglandin E2 and vascular endothelial growth factor on sperm might lead to endometriosis-associated infertility.
机构信息
Institute of Physiological and Anatomical Medicine, Department of Anatomy, Tzu Chi University, and Department of Obstetrics and Gynecology, Yuli Veterans Hospital, Hualien, Taiwan.
出版信息
Fertil Steril. 2011 Jan;95(1):360-2. doi: 10.1016/j.fertnstert.2010.08.040.
Significantly higher levels of prostaglandin E2 and vascular endothelial growth factor were associated with the severity of endometriosis. In this study, pathologic concentrations of prostaglandin E2 and vascular endothelial growth factor found in endometriotic women significantly inhibited sperm motility, acrosome reaction, and sperm-oocyte interaction, which might result in endometriosis-associated subfertility/infertility.
前列腺素 E2 和血管内皮生长因子水平显著升高与子宫内膜异位症的严重程度相关。在这项研究中，在子宫内膜异位症妇女中发现的病理性浓度的前列腺素 E2 和血管内皮生长因子显著抑制了精子的运动、顶体反应和精卵相互作用，这可能导致与子宫内膜异位症相关的生育力低下/不孕。
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