Nicolaïdis S, Even P C
Lab. Neurobiologie des Régulations, CNRS UA 637, College de France, Paris.
Int J Obes. 1990;14 Suppl 3:35-49; discussion 50-2.
The physiological mechanism of the control of feeding is analyzed in the light of the ischymetric hypothesis which proposes that feeding is controlled by the intensity of the metabolism free from the energetic cost of muscular effort. This part of the metabolism was designated métabolisme de fond. To measure métabolisme de fond in relation to feeding a specific metabolic device has been developed. It was shown that métabolisme de fond decreased before meals, either spontaneously or experimentally induced. Métabolisme de fond reached its zenith when the meal ended; i.e. métabolisme de fond is an excellent predictor of feeding responses. On the contrary, the respiratory quotient, which reflects the ratio of glucose to fat utilization did not exhibit any specific change in favor of a glucostatic or lipostatic mechanism. Therefore, it is proposed that the ischymetric model of feeding expresses the physiological mechanism of the control of feeding better than the various moleculostatic hypotheses, and particularly the glucostatic hypothesis.
根据等容假设分析了进食控制的生理机制，该假设提出进食受代谢强度控制，而不受肌肉活动能量消耗的影响。这部分代谢被称为基础代谢。为了测量与进食相关的基础代谢，已开发出一种特定的代谢装置。结果表明，基础代谢在餐前会自发或通过实验诱导而降低。基础代谢在进食结束时达到峰值；即基础代谢是进食反应的极佳预测指标。相反，反映葡萄糖与脂肪利用比例的呼吸商并未表现出任何有利于糖稳态或脂肪稳态机制的特定变化。因此，有人提出，进食的等容模型比各种分子稳态假设，特别是糖稳态假设，能更好地表达进食控制的生理机制。
