Vaccine and Infectious Disease, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Annu Rev Med. 2011;62:157-70. doi: 10.1146/annurev-med-050409-103711.
Cancer is increasingly recognized as a complication of HIV infection in both resource-rich and resource-limited areas. The traditional AIDS-defining cancers, including Kaposi sarcoma, cervical cancer, and non-Hodgkin lymphoma, have become common comorbidities afflicting HIV-positive individuals and lack adequate prevention and management options. Additionally, several non-AIDS-defining cancers have increased in incidence in resource-limited regions, including Hodgkin lymphoma, hepatocellular carcinoma, and lung cancer. This review outlines the epidemiology of HIV-associated malignancies in resource-poor and resource-rich areas, including the impact of highly active antiretroviral therapy on the incidence of these cancers. The pathogenesis of HIV-associated cancers is considered in relation to potential strategies for their prevention and treatment.
癌症在资源丰富和资源有限的地区都越来越被认为是 HIV 感染的并发症。传统的艾滋病定义癌症，包括卡波西肉瘤、宫颈癌和非霍奇金淋巴瘤，已经成为影响 HIV 阳性个体的常见合并症，且缺乏足够的预防和管理选择。此外，在资源有限的地区，几种非艾滋病定义的癌症的发病率也有所增加，包括霍奇金淋巴瘤、肝细胞癌和肺癌。这篇综述概述了资源匮乏和资源丰富地区与 HIV 相关的恶性肿瘤的流行病学，包括高效抗逆转录病毒疗法对这些癌症发病率的影响。还考虑了 HIV 相关癌症的发病机制与它们的预防和治疗的潜在策略的关系。
