Xu Yueli, Li Junjuan, Ding Zhaolei, Li Juan, Li Bin, Yu Zhengang, Tan Wei
Postgraduate Department of Internal Medicine, Weifang Medical University, Weifang, Shandong, China.
Department of Respiratory Medicine, Weifang People's Hospital, Weifang, Shandong, China.
Biosci Rep. 2017 Jan 27;37(1). doi: 10.1042/BSR20160505. Print 2017 Feb 28.
Asthma is a serious and hereditary respiratory disorder affecting all age groups. Interleukin-13 (IL-13) is a central regulator of allergic inflammation. The purpose of the present study was to estimate the relationship between IL-13 +1923C/T polymorphism and asthma susceptibility. Relevant case-control studies published between January 2000 and July 2016 were searched in the online databases. Review Manage (RevMan) 5.3 was used to conduct the statistical analysis. The pooled odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of association. A total of 26 articles were retrieved, including 17642 asthma patients and 42402 controls. Overall, our results found that IL-13 +1923C/T polymorphism was significantly associated with increased risk of asthma under each genetic model (P<0.00001). Subgroup analysis by ethnicity showed that alleles and genotypes of this variant correlated with asthma among Asians and Caucasians, but only TT genotype under the homozygote model in Africans. When stratified by age group, this variant highly correlated with asthma in children and moderately in adults. Furthermore, the TT, CT and CC genotypes in asthma group were all significantly associated with increased IgE levels in sera of asthma patients when compared with controls. Our results suggested that IL-13 +1923C/T polymorphism contributed to the development of asthma. Further case-control studies with more ethnicities are still needed.
哮喘是一种影响所有年龄组的严重遗传性呼吸系统疾病。白细胞介素-13（IL-13）是过敏性炎症的核心调节因子。本研究的目的是评估IL-13 +1923C/T多态性与哮喘易感性之间的关系。在在线数据库中检索了2000年1月至2016年7月期间发表的相关病例对照研究。使用Review Manage（RevMan）5.3进行统计分析。采用合并比值比（OR）及其95%置信区间（CI）来计算关联强度。共检索到26篇文章，包括17642例哮喘患者和42402例对照。总体而言，我们的结果发现，在每种遗传模型下，IL-13 +1923C/T多态性与哮喘风险增加显著相关（P<0.00001）。按种族进行的亚组分析表明，该变体的等位基因和基因型与亚洲人和高加索人的哮喘相关，但在非洲人中仅在纯合子模型下的TT基因型与哮喘相关。按年龄组分层时，该变体与儿童哮喘高度相关，与成人哮喘中度相关。此外，与对照组相比，哮喘组的TT、CT和CC基因型均与哮喘患者血清中IgE水平升高显著相关。我们的结果表明，IL-13 +1923C/T多态性促成了哮喘的发生。仍需要更多种族的进一步病例对照研究。
