间充质干细胞的免疫调节特性：对手术疾病的影响。
The immunomodulatory properties of mesenchymal stem cells: implications for surgical disease.
机构信息
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
出版信息
J Surg Res. 2011 May 1;167(1):78-86. doi: 10.1016/j.jss.2010.07.019. Epub 2010 Aug 6.
Abstract
Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.
摘要
间充质干细胞 (MSCs) 在治疗多种疾病的实验和临床中得到了应用。现在已经很清楚，许多不同的机制有助于这些细胞发挥治疗作用。MSCs 与多种免疫细胞相互作用并调节其功能的能力就是这样一种机制。本文综述了 MSCs 的免疫调节特性可能对实体器官排斥、全身炎症反应综合征、癌症和克罗恩病治疗的影响。
相似文献
1
The immunomodulatory properties of mesenchymal stem cells: implications for surgical disease.间充质干细胞的免疫调节特性：对手术疾病的影响。
J Surg Res. 2011 May 1;167(1):78-86. doi: 10.1016/j.jss.2010.07.019. Epub 2010 Aug 6.
2
Immunosuppressive properties of mesenchymal stem cells: advances and applications.间充质干细胞的免疫抑制特性：进展与应用。
Curr Mol Med. 2012 Jun;12(5):574-91. doi: 10.2174/156652412800619950.
3
Immunomodulatory Mechanisms of Mesenchymal Stem Cells and Their Potential Clinical Applications.间充质干细胞的免疫调节机制及其潜在的临床应用。
Int J Mol Sci. 2022 Sep 2;23(17):10023. doi: 10.3390/ijms231710023.
4
Role of mesenchymal stem cell therapy in Crohn's disease.间充质干细胞治疗克罗恩病的作用。
Pediatr Res. 2012 Apr;71(4 Pt 2):445-51. doi: 10.1038/pr.2011.56. Epub 2012 Feb 8.
5
In vitro And In vivo Immunomodulating Properties of Mesenchymal Stem Cells.间充质干细胞的体外和体内免疫调节特性
Recent Pat Inflamm Allergy Drug Discov. 2018;12(1):59-68. doi: 10.2174/1872213X12666180227105924.
6
Mesenchymal stem cells: ideal seeds for treating diseases.间充质干细胞：治疗疾病的理想种子。
Hum Cell. 2021 Nov;34(6):1585-1600. doi: 10.1007/s13577-021-00578-0. Epub 2021 Jul 16.
7
MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu.MIS416 通过调节全身免疫环境增强人脐带来源间充质干细胞对实验性结肠炎的治疗功能。
Front Immunol. 2018 May 28;9:1078. doi: 10.3389/fimmu.2018.01078. eCollection 2018.
8
The Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Diabetes Mellitus.间充质干细胞在糖尿病治疗中的治疗潜力
Cell Reprogram. 2022 Dec;24(6):329-342. doi: 10.1089/cell.2022.0039. Epub 2022 Jul 25.
9
Immunomodulatory Behavior of Mesenchymal Stem Cells.间充质干细胞的免疫调节行为。
Adv Exp Med Biol. 2018;1119:73-84. doi: 10.1007/5584_2018_255.
10
Immunomodulation effect of mesenchymal stem cells in islet transplantation.间充质干细胞在胰岛移植中的免疫调节作用。
Biomed Pharmacother. 2021 Oct;142:112042. doi: 10.1016/j.biopha.2021.112042. Epub 2021 Aug 14.
引用本文的文献
1
The Mechanisms Involved in Mesenchymal Stem Cell Alleviation of Sepsis-Induced Acute Lung Injury in Mice: A Pilot Study.间充质干细胞减轻小鼠脓毒症诱导的急性肺损伤的机制：一项初步研究
Curr Ther Res Clin Exp. 2020 Jul 8;93:100593. doi: 10.1016/j.curtheres.2020.100593. eCollection 2020.
2
Turning regenerative technologies into treatment to repair myocardial injuries.将再生技术转化为治疗方法，以修复心肌损伤。
J Cell Mol Med. 2020 Mar;24(5):2704-2716. doi: 10.1111/jcmm.14630. Epub 2019 Sep 30.
3
Bone marrow-derived mesenchymal stem cells ameliorate liver injury in a rat model of sepsis by activating Nrf2 signaling.骨髓间充质干细胞通过激活Nrf2信号通路改善脓毒症大鼠模型的肝损伤。
Histochem Cell Biol. 2019 Mar;151(3):249-262. doi: 10.1007/s00418-018-1731-4. Epub 2018 Sep 24.
4
Monocrotaline-Induced Pulmonary Hypertension Involves Downregulation of Antiaging Protein Klotho and eNOS Activity.野百合碱诱导的肺动脉高压涉及抗衰老蛋白α-klotho的下调和内皮型一氧化氮合酶活性降低。
Hypertension. 2016 Nov;68(5):1255-1263. doi: 10.1161/HYPERTENSIONAHA.116.08184. Epub 2016 Sep 26.
5
Mesenchymal stem cells as a therapeutic tool to treat sepsis.间充质干细胞作为治疗脓毒症的治疗工具。
World J Stem Cells. 2015 Mar 26;7(2):368-79. doi: 10.4252/wjsc.v7.i2.368.
6
The potential and challenges of using stem cells for cardiovascular repair and regeneration.使用干细胞进行心血管修复和再生的潜力与挑战。
Genes Dis. 2014 Sep 1;1(1):113-119. doi: 10.1016/j.gendis.2014.07.003.
7
Antioxidant Effects of Bone Marrow Mesenchymal Stem Cell against Carbon Tetrachloride-Induced Oxidative Damage in Rat Livers.骨髓间充质干细胞对四氯化碳诱导的大鼠肝脏氧化损伤的抗氧化作用
Int J Organ Transplant Med. 2014;5(4):166-73.
8
Effects of mesenchymal stem cell and fibroblast coating on immunogenic potential of prosthetic meshes in vitro.间充质干细胞和成纤维细胞包被对人工补片体外免疫原性潜能的影响
Surg Endosc. 2014 Aug;28(8):2357-67. doi: 10.1007/s00464-014-3470-5. Epub 2014 Jun 28.
9
Mesenchymal stem cell therapy for cardiac repair.用于心脏修复的间充质干细胞疗法。
Curr Treat Options Cardiovasc Med. 2014 Jul;16(7):323. doi: 10.1007/s11936-014-0323-4.
10
The Necessity of a Systematic Approach for the Use of MSCs in the Clinical Setting.在临床环境中使用间充质干细胞需要系统的方法。
Stem Cells Int. 2013;2013:892340. doi: 10.1155/2013/892340. Epub 2013 Jun 23.
本文引用的文献
1
Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta.间充质干细胞通过调节性 T 细胞保护乳腺癌细胞：间充质干细胞衍生的 TGF-β的作用。
J Immunol. 2010 May 15;184(10):5885-94. doi: 10.4049/jimmunol.0903143. Epub 2010 Apr 9.
2
Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment.间充质基质细胞单独或表达干扰素-β可抑制体内胰腺肿瘤，而抗炎治疗可拮抗这种作用。
Cytotherapy. 2010 Sep;12(5):615-25. doi: 10.3109/14653241003631815.
3
Ablation of TNF-alpha receptors influences mesenchymal stem cell-mediated cardiac protection against ischemia.肿瘤坏死因子-α受体的消融影响骨髓间充质干细胞介导的心肌缺血保护。
Shock. 2010 Sep;34(3):236-42. doi: 10.1097/SHK.0b013e3181d75ae3.
4
A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.一项随机、双盲、安慰剂对照、剂量递增的急性心肌梗死后静脉内输注成人异体间充质干细胞（Prochymal）的研究。
J Am Coll Cardiol. 2009 Dec 8;54(24):2277-86. doi: 10.1016/j.jacc.2009.06.055.
5
Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction.神经肽 Y 和间充质干细胞联合应用可逆转心肌梗死后的重构。
Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H275-86. doi: 10.1152/ajpheart.00765.2009. Epub 2009 Nov 6.
6
IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.表达白细胞介素-18结合蛋白的间充质干细胞可改善缺血或梗死后的心肌保护作用。
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17499-504. doi: 10.1073/pnas.0908924106. Epub 2009 Sep 25.
7
Mesenchymal stem cells as immunomodulators after liver transplantation.肝移植后作为免疫调节剂的间充质干细胞
Liver Transpl. 2009 Oct;15(10):1192-8. doi: 10.1002/lt.21862.
8
Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages.骨髓间充质干细胞来源的巨噬细胞：一种新型的经典激活型巨噬细胞。
Exp Hematol. 2009 Dec;37(12):1445-53. doi: 10.1016/j.exphem.2009.09.004. Epub 2009 Sep 20.
9
Toward MSC in solid organ transplantation: 2008 position paper of the MISOT study group.迈向实体器官移植中的间充质干细胞：MISOT研究组2008年立场文件
Transplantation. 2009 Sep 15;88(5):614-9. doi: 10.1097/TP.0b013e3181b4425a.
10
Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.异体人骨髓间充质干细胞用于治疗体外灌注人肺中大肠杆菌内毒素诱导的急性肺损伤。
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16357-62. doi: 10.1073/pnas.0907996106. Epub 2009 Aug 31.
Zotero 插件