Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
J Surg Res. 2011 May 1;167(1):78-86. doi: 10.1016/j.jss.2010.07.019. Epub 2010 Aug 6.
Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.
间充质干细胞 (MSCs) 在治疗多种疾病的实验和临床中得到了应用。现在已经很清楚，许多不同的机制有助于这些细胞发挥治疗作用。MSCs 与多种免疫细胞相互作用并调节其功能的能力就是这样一种机制。本文综述了 MSCs 的免疫调节特性可能对实体器官排斥、全身炎症反应综合征、癌症和克罗恩病治疗的影响。
