Department of Neurology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA.
Vaccine. 2011 Jan 29;29(5):886-9. doi: 10.1016/j.vaccine.2010.09.020. Epub 2010 Sep 23.
Using data from Vaccine Adverse Event Reporting System, we identified 69 reports of Guillain-Barré Syndrome (GBS) after Gardasil vaccination that occurred in the United States between 2006 and 2009. The onset of symptoms was within 6 weeks after vaccination in 70% of the patients in whom the date of vaccination was known. The estimated weekly reporting rate of post-Gardasil GBS within the first 6 weeks (6.6 per 10,000,000) was higher than that of the general population, and higher than post-Menactra and post-influenza vaccinations. Further prospective active surveillance for accurate ascertainment and identification of high-risk groups of GBS after Gardasil vaccination is warranted.
利用疫苗不良事件报告系统的数据，我们在美国 2006 年至 2009 年期间发现了 69 例接种 Gardasil 后发生的格林-巴利综合征（GBS）报告。在已知接种日期的患者中，70%的患者症状在接种后 6 周内出现。接种 Gardasil 后前 6 周内（6.6/1000 万）GBS 的估计每周报告率高于普通人群，也高于接种 Menactra 和流感疫苗后。需要进一步进行前瞻性主动监测，以准确确定 Gardasil 接种后 GBS 的高危人群。
