Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA 19104, USA.
Biomaterials. 2011 Jan;32(1):87-94. doi: 10.1016/j.biomaterials.2010.08.090. Epub 2010 Sep 24.
Superior mechanical properties, rich surface chemistry, and good biocompatibility of diamond nanoparticles make them attractive in biomaterial applications. A multifunctional fluorescent composite bone scaffold material has been produced utilizing a biodegradable polymer, poly(l-lactic acid) (PLLA), and octadecylamine-functionalized nanodiamond (ND-ODA). The uniform dispersion of nanoparticles in the polymer led to significant increase in hardness and Young's modulus of the composites. Addition of 10%wt of ND-ODA resulted in more than 200% increase in Young's modulus and 800% increase in hardness, bringing the nanocomposite properties close to that of the human cortical bone. Testing of ND-ODA/PLLA as a matrix supporting murine osteoblast (7F2) cell growth for up to 1 week showed that the addition of ND-ODA had no negative effects on cell proliferation. ND-ODA serves as a multifunctional additive providing improved mechanical properties, bright fluorescence, and options for drug loading and delivery via surface modification. Thus ND-ODA/PLLA composites open up numerous avenues for their use as components of bone scaffolds and smart surgical tools such as fixation devices in musculoskeletal tissue engineering and regenerative medicine. Intense fluorescence of ND-ODA/PLLA scaffolds can be used to monitor bone re-growth replacing the implant in vivo.
纳米金刚石具有优越的力学性能、丰富的表面化学性质和良好的生物相容性，因此在生物材料应用中具有吸引力。利用可生物降解的聚合物聚（L-乳酸）（PLLA）和十八胺功能化纳米金刚石（ND-ODA）制备了一种多功能荧光复合骨支架材料。纳米粒子在聚合物中的均匀分散导致复合材料的硬度和杨氏模量显著提高。添加 10wt%的 ND-ODA 可使杨氏模量增加超过 200%，硬度增加超过 800%，使纳米复合材料的性能接近人皮质骨。对 ND-ODA/PLLA 作为支持鼠成骨细胞（7F2）生长长达 1 周的基质进行测试表明，添加 ND-ODA 对细胞增殖没有负面影响。ND-ODA 作为一种多功能添加剂，提供了改进的力学性能、明亮的荧光，并通过表面修饰提供了药物负载和递送的选择。因此，ND-ODA/PLLA 复合材料为其在骨支架和智能手术工具（如肌肉骨骼组织工程和再生医学中的固定装置）中的应用开辟了许多途径。ND-ODA/PLLA 支架的强荧光可用于监测体内植入物替代的骨再生。
