Institute for Microbiology and Genetics, University of Göttingen, Grisebachstr. 8, D-37077 Göttingen, Germany.
Curr Opin Microbiol. 2010 Dec;13(6):663-71. doi: 10.1016/j.mib.2010.08.010. Epub 2010 Sep 24.
NDR kinases are crucial for growth, differentiation, and pathogenicity in all analyzed fungal species. They require association with MOB co-activators and several scaffolding proteins for their function. Phosphorylation of two conserved residues in the activation segment and the hydrophobic motif controls the transition between an enzymatic inactive, basal active, and fully active state of the NDR kinase. Although cellular functions of NDR kinases are only beginning to emerge, regulation of small G-proteins of the Rho and Rab families and combinatorial transcriptional and translational regulation of gene expression are conserved signaling patterns among fungal and higher eukaryotic NDR kinase pathways.
NDR 激酶对于所有分析的真菌物种的生长、分化和致病性至关重要。它们的功能需要与 MOB 共激活因子和几种支架蛋白结合。在激活片段和疏水性基序中的两个保守残基的磷酸化控制着 NDR 激酶从酶失活、基础活性到完全活性状态的转变。尽管 NDR 激酶的细胞功能才刚刚开始显现，但 Rho 和 Rab 家族的小 G 蛋白的调节以及真菌和高等真核生物 NDR 激酶途径中基因表达的组合转录和翻译调节是保守的信号模式。
