Siegert G
Institut für klinische Chemie und Laboratoriumsdiagnostik, Medizinische Akademie Dresden.
Klin Wochenschr. 1990;68 Suppl 22:122.
Plasma was obtained from fasting normolipemic healthy donors, 150 minutes past fat intake (1 g/kg body weight). Lipoproteins were isolated by sequential and density gradient ultracentrifugation. All lipoprotein fractions from fasting plasma did not show any inhibitory effect of fibrinolysis, whereas postprandial triglyceride-rich fractions (chylomicrons and VLDL) showed inhibitory effects of plasmin induced fibrinolysis. The inhibitor was identified as alpha-2-antiplasmin associated with chylomicrons and VLDL but lipoproteins itself are not responsible for inhibitory effect. It is possible that association is responsible for elevation of alpha-2-antiplasmin in patients with hypertriglycidemia.
血浆取自血脂正常的空腹健康供体，脂肪摄入（1克/千克体重）后150分钟。脂蛋白通过连续和密度梯度超速离心法分离。空腹血浆中的所有脂蛋白组分均未显示出对纤维蛋白溶解的任何抑制作用，而餐后富含甘油三酯的组分（乳糜微粒和极低密度脂蛋白）显示出对纤溶酶诱导的纤维蛋白溶解的抑制作用。该抑制剂被鉴定为与乳糜微粒和极低密度脂蛋白相关的α-2-抗纤溶酶，但脂蛋白本身并不负责这种抑制作用。有可能这种关联导致了高甘油三酯血症患者中α-2-抗纤溶酶的升高。
