Kuz'mina Iu L, Panov V V, Vorob'eva N E, Soshnikova N V, Kopantseva M R, Nikolenko Iu V, Nabirochkina E N, Georgieva S G, Shidlovskiĭ Iu V
Genetika. 2010 Aug;46(8):1033-40.
SAYP is a dual-function transcriptional coactivator of RNA polymerase II. It is a metazoan-specific factor involved in different signaling pathways that control normal development. In Drosophila, SAYP is present in the organism from the early stages of development and participates in cell cycle synchronization at the blastoderm stage. SAYP is abundant in many embryonic cells and in imaginal discs of larvae and is crucial for oogenesis in adults. At the molecular level, SAYP serves as a basis for assembling the BTFly nuclear supercomplex consising of the Brahma and TFIID coactivators. We suppose that BTFly and other similar nuclear supercomplexes play an important role in ontogenesis.
SAYP是RNA聚合酶II的双功能转录共激活因子。它是一种后生动物特有的因子，参与控制正常发育的不同信号通路。在果蝇中，SAYP从发育早期就存在于生物体中，并参与胚盘阶段的细胞周期同步。SAYP在许多胚胎细胞以及幼虫的成虫盘细胞中含量丰富，对成虫的卵子发生至关重要。在分子水平上，SAYP是组装由Brahma和TFIID共激活因子组成的BTFly核超级复合体的基础。我们推测BTFly和其他类似的核超级复合体在个体发育中起重要作用。
