Vorob'eva N E, Soshnikova N V, Nikolenko Iu V, Kuz'mina Iu L, Nabirochkina E N, Georgieva S G, Shidlovskiĭ Iu V
Mol Biol (Mosk). 2010 Sep-Oct;44(5):867-75.
In the S2 cell system of Drosophila melanogaster a key protein domain mediating the interaction of TFIID and Brahma transcriptional complexes into the BTFly supercomplex has been shown to be an evolutionary conserved SAY domain of the SAYP. TFIID and Brahma coactivators participated in the reporter gene activation induced by the SAY domain in cellular nuclei. The TFIID and Brahma components directly interacting with the SAY domain were identified.
在黑腹果蝇的S2细胞系统中，已证明介导TFIID和Brahma转录复合物相互作用形成BTFly超复合物的关键蛋白结构域是SAYP的一个进化保守的SAY结构域。TFIID和Brahma共激活因子参与了细胞核中由SAY结构域诱导的报告基因激活。鉴定出了与SAY结构域直接相互作用的TFIID和Brahma组分。
