Department of Regulation of Genes Expression, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia.
Nucleic Acids Res. 2012 Mar;40(6):2445-53. doi: 10.1093/nar/gkr1165. Epub 2011 Nov 28.
Jak/STAT is an important signaling pathway mediating multiple events in development. We describe participation of metazoan co-activator SAYP/PHF10 in this pathway downstream of STAT. The latter, via its activation domain, interacts with the conserved core of SAYP. STAT is associated with the SAYP-containing co-activator complex BTFly and recruits BTFly onto genes. SAYP is necessary for stimulating STAT-driven transcription of numerous genes. Mutation of SAYP leads to maldevelopments similar to those observed in STAT mutants. Thus, SAYP is a novel co-activator mediating the action of STAT.
Jak/STAT 是一条重要的信号通路，介导了发育过程中的多种事件。我们描述了后生动物共激活因子 SAYP/PHF10 在 STAT 下游参与这一通路。后者通过其激活结构域与 SAYP 的保守核心相互作用。STAT 与包含 SAYP 的共激活因子复合物 BTFly 相关，并将 BTFly 募集到基因上。SAYP 对于刺激 STAT 驱动的众多基因的转录是必需的。SAYP 的突变导致与 STAT 突变体观察到的相似的发育异常。因此，SAYP 是一种介导 STAT 作用的新型共激活因子。
