Kushnerova N F, Rakhmanin Iu A, Kushnerova T V, Drugova E S
Gig Sanit. 2010 Jul-Aug(4):17-21.
Experimental studies were conducted on 4 groups of 10 rats each: 1) intact animals (a control group); 2) inhalation of carbon disulfide at a concentration of 2.0 mg/m3 for 7 days; 3) prophylactic administration of the hepatoprotective agent Legalon (100 mg/kg of total polyphenols), followed by carbon disulfide inhalation for 7 days; 4) prophylactic administration of the biologically active additive Kalifen (100 mg/kg of total polyphenols for 7 days), followed by carbon disulfide inhalation. Animal survival after carbon disulfide inhalation was 80%; preadministration of Legalon or Kalifen increased survival up to 100%. Carbon disulfide inhalation was attended by abnormal size features of red blood cells, impairments in the antioxidant defense system and the ratio of phospholipid fractions to neutral lipids. Preadministration of Legalon or Kalifen before inhalation contributes to less abnormalities in the study physiological and biochemical parameters of erythrocyte membranes.
对4组大鼠进行了实验研究，每组10只：1）完整动物（对照组）；2）以2.0毫克/立方米的浓度吸入二硫化碳7天；3）预防性给予肝保护剂利加隆（总多酚100毫克/千克），随后吸入二硫化碳7天；4）预防性给予生物活性添加剂卡利芬（总多酚100毫克/千克，持续7天），随后吸入二硫化碳。吸入二硫化碳后动物存活率为80%；预先给予利加隆或卡利芬可使存活率提高至100%。吸入二硫化碳伴随着红细胞大小特征异常、抗氧化防御系统受损以及磷脂组分与中性脂质的比例变化。在吸入前预先给予利加隆或卡利芬有助于减少红细胞膜研究生理和生化参数中的异常情况。
