Khalkova Zh, Vangelova K, Zaĭkov Kh
Probl Khig. 1995;20:162-71.
Artichoke, a new Bulgarian preparation based on the plant Cynara scolymus, was tested for influence on sympatho-adrenal system (SAS) activity in experimental inhalation exposure to carbon disulfide. This chronic (six-month) inhalation experiment was done on Wistar albino rats of either sex. Activity of SAS was assessed through excretion of noradrenalin and adrenalin. Findings indicated a phasic SAS response depending on concentration and duration of carbon disulfide exposure. With exposure to 30 mg.m3, SAS activity was observed to decrease in the second month, followed by increase in the fourth and sixth months. With exposure to 300 mg.m3, SAS activity was elevated over the whole period of study. Under the influence of the preparation artichoke at dosage 200 mg.kg-1, catecholamines, increased by carbon disulfide exposure, returned to normal. This trend was more marked for noradrenalin.
洋蓟是一种基于朝鲜蓟植物的新型保加利亚制剂，在实验性吸入二硫化碳暴露中，对其影响交感肾上腺系统（SAS）活性进行了测试。这项慢性（六个月）吸入实验是在不同性别的Wistar白化大鼠身上进行的。通过去甲肾上腺素和肾上腺素的排泄来评估SAS的活性。研究结果表明，SAS的反应呈阶段性，取决于二硫化碳暴露的浓度和持续时间。暴露于30毫克/立方米时，在第二个月观察到SAS活性下降，随后在第四个月和第六个月增加。暴露于300毫克/立方米时，在整个研究期间SAS活性升高。在200毫克/千克剂量的洋蓟制剂的影响下，因二硫化碳暴露而增加的儿茶酚胺恢复正常。这种趋势对去甲肾上腺素更为明显。
