Ringel K, Klotz E, Wenzel-Hora B I
Fortschr Geb Rontgenstrahlen Nuklearmed Erganzungsbd. 1989;128:153-7.
Iotrolan is a new nonionic, dimeric contrast medium that is distinguished by its special physicochemical and low chemotoxic properties. It displays near isotonicity with blood and cerebrospinal fluid in all clinically used concentrations (190, 240, and 300 mg I/ml). The controlled, double-blind study of iotrolan versus iopamidol presented here shows that iotrolan is significantly superior to the monomeric contrast medium in lumbar and direct cervical myelography. Use of the dimeric contrast medium reduced not only the incidence of side effects, but also their severity and duration. The chemotoxicity of contrast media commonly used was significantly less with iotrolan in all neuroradiologic diagnostic studies of the spine. The diagnostic quality of lumbar and direct cervical myelography with iotrolan was high. In this randomized, double-blind study versus iopamidol, iotrolan proved to be the safer and better myelographic agent for contrast studies of the spinal canal.
碘曲仑是一种新型非离子二聚体造影剂，其具有特殊的物理化学性质和低化学毒性。在所有临床使用浓度（190、240和300mg I/ml）下，它与血液和脑脊液呈现近等渗性。本文展示的碘曲仑与碘帕醇的对照双盲研究表明，在腰椎和直接颈椎脊髓造影中，碘曲仑显著优于单体造影剂。使用二聚体造影剂不仅降低了副作用的发生率，还降低了其严重程度和持续时间。在脊柱的所有神经放射学诊断研究中，碘曲仑的化学毒性明显低于常用造影剂。使用碘曲仑进行腰椎和直接颈椎脊髓造影的诊断质量很高。在这项与碘帕醇对比的随机双盲研究中，碘曲仑被证明是用于椎管造影研究更安全、更好的脊髓造影剂。
