碱性磷酸酶和体脂肪百分比可预测绝经前妇女的循环 C 反应蛋白。
Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women.
机构信息
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555-1109, USA.
出版信息
Biomarkers. 2010 Dec;15(8):663-70. doi: 10.3109/1354750X.2010.509811. Epub 2010 Sep 29.
Abstract
C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R(2)=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.
摘要
C-反应蛋白（CRP）被认为是炎症的标志物，而炎症是许多慢性疾病的危险因素。然而，CRP 的决定因素尚不清楚，本研究在一个严格定义的健康绝经前妇女队列（n=233）中使用多元回归模型进行了研究。血清 CRP 的独立预测因子（模型 R²=0.59）为体脂百分比、血清碱性磷酸酶（ALP）、性激素结合球蛋白和白细胞计数。CRP 与 ALP 密切相关，提示 ALP 的酶活性可能对 CRP 的抗炎作用很重要，这需要进一步的研究来证实。
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