Hayes F A, Feldman S
Cancer. 1978 Jul;42(1):159-63. doi: 10.1002/1097-0142(197807)42:1<159::aid-cncr2820420126>3.0.co;2-e.
Stimulation of lymphocytes by varicella-zoster virus (VZV) antigen was measured in vitro for 37 healthy adults and children and for 35 children who developed herpes zoster or varicella while receiving anticancer therapy. For 35 of the control group the history of varicella infection correlated with the in vitro response of lymphocytes to VZV antigen. A specific lymphocyte response was observed following 32 of the 37 episodes of VZV infection in the 35 children with malignancy. Re-evaluation 7--12 months following the acute infection revealed that the in vitro response to VZV antigen was lost in six of 19 patients who remained in remission and in all patients who relapsed and received reinduction therapy. Although there was some suggestion that development of a cell mediated response early in the infection decreased the incidence of skin dissemination of the virus in herpes zoster, no consistent correlation could be made between lymphocyte responsiveness in vitro and dissemination of disease or the duration of the appearance of new lesions.
对37名健康成人和儿童以及35名在接受抗癌治疗时患上带状疱疹或水痘的儿童，在体外检测了水痘-带状疱疹病毒（VZV）抗原对淋巴细胞的刺激作用。在对照组的35人中，水痘感染史与淋巴细胞对VZV抗原的体外反应相关。在35名患恶性疾病的儿童中，37次VZV感染中的32次出现了特异性淋巴细胞反应。急性感染后7至12个月的重新评估显示，19名仍处于缓解期的患者中有6名以及所有复发并接受再次诱导治疗的患者，其对VZV抗原的体外反应消失。尽管有迹象表明感染早期细胞介导反应的出现可降低带状疱疹中病毒皮肤播散的发生率，但体外淋巴细胞反应性与疾病播散或新皮损出现持续时间之间并无一致的相关性。
