老年人对水痘-带状疱疹病毒抗原的淋巴细胞增殖反应降低。
Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged.
作者信息
Berger R, Florent G, Just M
出版信息
Infect Immun. 1981 Apr;32(1):24-7. doi: 10.1128/iai.32.1.24-27.1981.
Abstract
Humoral antibodies and specific cellular immune reactions (proliferative immune response in the lymphocyte transformation test) to varicella-zoster virus antigen were measured in children, young adults, and elderly people. In children and young adults, the humoral varicella-zoster-specific antibodies and the virus-specific cellular immune response generally coincided. In the over-60 age group, however, a discrepancy was often observed between these parameters. Ninety percent of the elderly subjects showed humoral antibodies, but only 64% still had a measurable varicella-zoster-specific immune response. There was no correlation between the magnitude of the virus antigen-specific immune response and the mitogen-induced lymphoproliferative response (phytohemagglutinin stimulation). One in three elderly people, therefore, showed no cellular immune response to the varicella-zoster virus antigen, and this person could probably be regarded as a potential herpes zoster patient.
摘要
对儿童、青年人和老年人检测了针对水痘-带状疱疹病毒抗原的体液抗体和特异性细胞免疫反应（淋巴细胞转化试验中的增殖性免疫反应）。在儿童和青年人中，水痘-带状疱疹特异性体液抗体和病毒特异性细胞免疫反应通常是一致的。然而，在60岁以上年龄组中，这些参数之间经常观察到差异。90%的老年受试者显示有体液抗体，但只有64%仍有可测量的水痘-带状疱疹特异性免疫反应。病毒抗原特异性免疫反应的强度与丝裂原诱导的淋巴细胞增殖反应（植物血凝素刺激）之间没有相关性。因此，三分之一的老年人对水痘-带状疱疹病毒抗原没有细胞免疫反应，这个人可能被视为潜在的带状疱疹患者。
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