Ruckdeschel J C, Schimpff S C, Smyth A C, Mardiney M R
Am J Med. 1977 Jan;62(1):77-85. doi: 10.1016/0002-9343(77)90352-7.
Thirty-two patients with Hodgkin's disease and 12 normal donors were studied for their in vitro lymphocyte responsiveness to a membrane-associated varicella-zoster (VZ) antigen. When compared to the normal donors, patients with Hodgkin's disease in whom radiotherapy was recently completed and those with active, recurrent disease had markedly impaired cell-associated immunity to VZ antigen. In addition, there was a suggestion that patients in long-term remission who had received primary combined modality therapy (radiotherapy plus chemotherapy) had an impaired response when compared to normal persons or to patients who had received single modality therapy. Newly diagnosed, untreated patients with Hodgkin's disease did not differ significantly from normal persons as a group but two of six were unresponsive to the VZ antigen whereas all normal subjects were responsive. Most patients in remission for at least one year following therapy had normal in vitro responsiveness. In two patients herpes zoster developed after the demonstration of absent in vitro lymphocyte reactivity to the VZ antigen.
对32例霍奇金病患者和12名正常供者进行了研究，观察他们的体外淋巴细胞对膜相关水痘-带状疱疹（VZ）抗原的反应性。与正常供者相比，近期完成放疗的霍奇金病患者以及患有活动性复发性疾病的患者对VZ抗原的细胞相关免疫明显受损。此外，有迹象表明，接受过原发性综合治疗（放疗加化疗）的长期缓解患者与正常人和接受单一治疗的患者相比，反应受损。新诊断的未经治疗的霍奇金病患者作为一个群体与正常人没有显著差异，但6例中有2例对VZ抗原无反应，而所有正常受试者均有反应。大多数治疗后缓解至少一年的患者体外反应性正常。在2例患者中，在证明体外淋巴细胞对VZ抗原无反应后发生了带状疱疹。
