Curi C M, Ribeiro E B, Zaia C T, Dolnikoff M S
Department of Physiology, Escola Paulista de Medicina, São Paulo SP, Brazil.
Pharmacol Biochem Behav. 1990 Nov;37(3):399-403. doi: 10.1016/0091-3057(90)90003-z.
Stress was induced by short-term ether exposure (2 min) and tail vein puncture in normal (SO), adrenodemedullated (ADM), and adrenalectomized (ADR) rats. In ADM and SO rats stress provoked a significant hyperglycemic response with no change in plasma insulin levels. In ADR rats, on the other hand, the hyperglycemic response was not present. Actually, a significant rapid decrease in blood glucose, plasma insulin and hepatic glycogen content was observed. When the hypoglycemic effect of stress was prevented by glucose injection into ADR rats the decrease in plasma insulin and hepatic glycogen was not observed. The data suggest that the fall in plasma insulin and hepatic glycogen content observed in ADR animals result from an activation of the sympathetic nervous system induced by the decrease in blood glucose.
通过对正常（SO）、肾上腺髓质切除（ADM）和肾上腺切除（ADR）大鼠进行短期乙醚暴露（2分钟）和尾静脉穿刺诱导应激。在ADM和SO大鼠中，应激引发了显著的高血糖反应，而血浆胰岛素水平没有变化。另一方面，ADR大鼠没有出现高血糖反应。实际上，观察到血糖、血浆胰岛素和肝糖原含量显著快速下降。当通过给ADR大鼠注射葡萄糖来预防应激的低血糖作用时，未观察到血浆胰岛素和肝糖原的下降。数据表明，在ADR动物中观察到的血浆胰岛素和肝糖原含量下降是由血糖降低诱导的交感神经系统激活所致。
