Laboratory of Cellular and Molecular Immunology, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Clin Exp Allergy. 2010 Dec;40(12):1755-9. doi: 10.1111/j.1365-2222.2010.03618.x. Epub 2010 Sep 28.
Asthma is characterized by chronic inflammation of the airways with significant changes in leucocyte trafficking, cellular activation and tissue remodelling. Brain-derived neurotrophic factor (BDNF) has been involved with asthma and allergic diseases but its role as a severity marker in paediatric asthma has not been clinically assessed.
To evaluate plasma BDNF and inflammatory markers in order to address their relationships with disease severity in children (6-15 years) with controlled persistent asthma.
Children with persistent asthma were selected and lung function and skin prick tests were performed in all patients. Plasma BDNF levels and various inflammatory markers (CCL3, CCL11, CCL22, CCL24, CXCL8, CXCL9, CXCL10, soluble TNF receptors) were assessed by ELISAs.
Subjects with moderate and severe asthma had higher BDNF levels than mild asthma and controls (P<0.001). The chemokines studied and soluble TNF receptors did not differ between the studied groups.
Our results indicate BDNF as a potential biomarker for clinical severity in children with asthma.
哮喘的特征是气道慢性炎症，白细胞迁移、细胞活化和组织重塑发生显著变化。脑源性神经营养因子（BDNF）与哮喘和过敏性疾病有关，但尚未在儿科哮喘中对其作为严重程度标志物的作用进行临床评估。
评估哮喘患儿（6-15 岁）血浆 BDNF 和炎症标志物的水平，以探讨它们与疾病严重程度的关系。
选择持续性哮喘患儿，对所有患者进行肺功能和皮肤点刺试验。通过 ELISA 法检测血浆 BDNF 水平和各种炎症标志物（CCL3、CCL11、CCL22、CCL24、CXCL8、CXCL9、CXCL10、可溶性 TNF 受体）。
中重度哮喘患儿的 BDNF 水平高于轻度哮喘患儿和对照组（P<0.001）。所研究的趋化因子和可溶性 TNF 受体在研究组之间无差异。
我们的研究结果表明，BDNF 可作为哮喘患儿临床严重程度的潜在生物标志物。
