Forsgren Sture, Grimsholm Ola, Dalén Tore, Rantapää-Dahlqvist Solbritt
Anatomy Section, Department of Integrative Medical Biology, Umeå University, 901 87 Umeå, Sweden.
Int J Inflam. 2011;2011:650685. doi: 10.4061/2011/650685. Epub 2011 Jun 8.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin with functions related to neuronal survival/proliferation processes and inflammation. BDNF is also an important central pain mediator. The levels of BDNF have been found to be high for RA patients with severe disease and to become lowered in response to anti-TNF treatment. New information says that the levels of BDNF in the blood parallel the BDNF concentrations in the brain and that BDNF can pass the blood-brain barrier. Furthermore, most of the circulating BDNF is produced in the brain. Habitual and regular exercise, in contrast to temporary exercise, does also lead to a lowering of BDNF blood levels. Both anti-TNF treatment and habitual and regular exercise do have pain-relieving effects. It might be that the pain-relieving effect of anti-TNF treatment is related to an affection of central neuronal regions, hereby influencing BDNF production. Measurements of BDNF in the blood help us to clarify the magnitude of centrally related pain for RA patients and help us to explain the relief of this pain in response to anti-TNF treatment.
脑源性神经营养因子（BDNF）是一种神经营养蛋白，其功能与神经元存活/增殖过程及炎症相关。BDNF也是一种重要的中枢性疼痛介质。已发现，重症类风湿关节炎（RA）患者的BDNF水平较高，而在接受抗TNF治疗后会降低。新信息表明，血液中BDNF的水平与大脑中BDNF的浓度平行，且BDNF能够通过血脑屏障。此外，循环中的BDNF大部分是由大脑产生的。与临时运动相比，习惯性规律运动也会导致血液中BDNF水平降低。抗TNF治疗和习惯性规律运动均具有止痛作用。抗TNF治疗的止痛效果可能与中枢神经元区域受到影响有关，从而影响BDNF的产生。检测血液中的BDNF有助于我们明确RA患者中枢性相关疼痛的程度，并有助于解释抗TNF治疗后这种疼痛得到缓解的原因。
