健康志愿者纹状体多巴胺 D(2)/D(3)受体可及性的阳光暴露变化。
Sunshine-exposure variation of human striatal dopamine D(2)/D(3) receptor availability in healthy volunteers.
机构信息
Department of Psychiatry, St Martin De Porres Hospital, Chiayi, Taiwan.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):107-10. doi: 10.1016/j.pnpbp.2010.09.014. Epub 2010 Sep 26.
BACKGROUND
In addition to the serotonergic system, the central dopaminergic system has been reported to be correlated with seasonality. The aim of this study was to explore the difference in striatal dopamine D(2)/D(3) receptor availability between healthy volunteers who had a high-sunshine exposure and those who had a low exposure.
METHODS
Sixty-eight participants were enrolled, and those in the upper and lower quartiles in terms of sunshine exposure were categorized into high- (n = 17) and low-sunshine-exposure (n = 18) subgroups. Single photon emission computed tomography with [(123)I] iodo-benzamide was used to measure striatal dopamine D(2)/D(3) receptor availability.
RESULTS
Striatal dopamine D(2)/D(3) receptor availability was significantly greater in the subjects with high-sunshine exposure than in those with low-sunshine exposure (F = 7.97, p = 0.01) after controlling for age, sex, and smoking status.
LIMITATIONS
Different subjects were examined at different time points in our study. In addition, the sex and tobacco use distributions differed between groups.
CONCLUSION
The central dopaminergic system may play a role in the neurobiological characteristics of sunshine-exposure variation.
背景
除了 5-羟色胺能系统外，中枢多巴胺能系统也被报道与季节性有关。本研究的目的是探讨具有高阳光暴露和低阳光暴露的健康志愿者之间纹状体多巴胺 D2/D3 受体可用性的差异。
方法
共纳入 68 名参与者，根据阳光暴露的上四分位数和下四分位数，将其分为高阳光暴露组（n=17）和低阳光暴露组（n=18）。使用 [(123)I]碘苯酰胺单光子发射计算机断层扫描来测量纹状体多巴胺 D2/D3 受体可用性。
结果
在控制年龄、性别和吸烟状况后，高阳光暴露组的纹状体多巴胺 D2/D3 受体可用性显著高于低阳光暴露组（F=7.97，p=0.01）。
局限性
在我们的研究中，不同的受试者在不同的时间点进行检查。此外，组间的性别和烟草使用分布不同。
结论
中枢多巴胺能系统可能在阳光暴露变化的神经生物学特征中起作用。
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