脑卒中后神经修复治疗的靶点。
Targets for neural repair therapies after stroke.
机构信息
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
出版信息
Stroke. 2010 Oct;41(10 Suppl):S124-6. doi: 10.1161/STROKEAHA.110.597146.
Abstract
Studies of neural repair after stroke have developed from a relatively small number of laboratories doing highly creative discovery science to a field in which reproducible evidence supports distinct pathways, processes, and molecules that promote recovery. This review focuses on some emerging targets for neural repair or recovery in stroke and on their limitations.
摘要
脑卒中后神经修复研究已从少数实验室进行高度创造性的发现科学发展为一个领域，其中可重复的证据支持促进恢复的明确途径、过程和分子。本文重点介绍了脑卒中神经修复或恢复的一些新靶点及其局限性。
相似文献
1
Targets for neural repair therapies after stroke.脑卒中后神经修复治疗的靶点。
Stroke. 2010 Oct;41(10 Suppl):S124-6. doi: 10.1161/STROKEAHA.110.597146.
2
Modulating Astrocyte Transition after Stroke to Promote Brain Rescue and Functional Recovery: Emerging Targets Include Rho Kinase.调控卒中后星形胶质细胞转化以促进脑保护和功能恢复：新兴靶点包括 Rho 激酶。
Int J Mol Sci. 2016 Feb 26;17(3):288. doi: 10.3390/ijms17030288.
3
Astrocyte-Derived Exosomes Treated With a Semaphorin 3A Inhibitor Enhance Stroke Recovery via Prostaglandin D Synthase.星形胶质细胞衍生的外泌体经信号素 3A 抑制剂处理后通过前列腺素 D 合酶增强中风恢复。
Stroke. 2018 Oct;49(10):2483-2494. doi: 10.1161/STROKEAHA.118.021272.
4
Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice.星形胶质细胞白细胞介素-17A在成年小鼠中风后存活及神经前体细胞神经元分化中的关键作用
Cell Death Dis. 2016 Jun 23;7(6):e2273. doi: 10.1038/cddis.2015.284.
5
Time to Target Stroke: Examining the Circadian System in Stroke.目标时间到：研究中风的昼夜节律系统。
Yale J Biol Med. 2019 Jun 27;92(2):349-357. eCollection 2019 Jun.
6
Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke.新型 Nec-1 类似物 DTIO 在缺血性脑卒中急慢性期的神经保护作用
Neuroscience. 2018 Oct 15;390:12-29. doi: 10.1016/j.neuroscience.2018.07.044. Epub 2018 Aug 2.
7
Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function.中风中的反应性星形胶质细胞增生：星形胶质细胞对神经功能恢复的作用。
Neurochem Int. 2017 Jul;107:88-103. doi: 10.1016/j.neuint.2016.12.016. Epub 2017 Jan 3.
8
Emergent properties of neural repair: elemental biology to therapeutic concepts.神经修复的涌现特性：从基础生物学到治疗理念
Ann Neurol. 2016 Jun;79(6):895-906. doi: 10.1002/ana.24653. Epub 2016 Apr 21.
9
Astrocytic nutritional dysfunction associated with hypoxia-induced neuronal vulnerability in stroke-prone spontaneously hypertensive rats.与易卒中型自发性高血压大鼠缺氧诱导神经元易损性相关的星形胶质细胞营养功能障碍。
Neurochem Int. 2020 Sep;138:104786. doi: 10.1016/j.neuint.2020.104786. Epub 2020 Jun 21.
10
Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes.神经干细胞移植通过上调星形胶质细胞中的谷氨酸转运体GLT-1诱导中风恢复。
J Neurosci. 2016 Oct 12;36(41):10529-10544. doi: 10.1523/JNEUROSCI.1643-16.2016.
引用本文的文献
1
Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke.抑制 CSPG 受体 PTPσ 可促进新生神经细胞的迁移、轴突的出芽和中风的恢复。
Cell Rep. 2022 Jul 26;40(4):111137. doi: 10.1016/j.celrep.2022.111137.
2
Nogo-A receptor internalization by cyclic adenosine monophosphate in overcoming axonal growth inhibitors after stroke.环磷酸腺苷介导的Nogo-A受体内化在克服中风后轴突生长抑制中的作用
Neural Regen Res. 2022 Jan;17(1):91-92. doi: 10.4103/1673-5374.314298.
3
Meningeal Multipotent Cells: A Hidden Target for CNS Repair?脑膜多能细胞：中枢神经系统修复的隐藏靶点？
Neuromolecular Med. 2021 Sep;23(3):339-343. doi: 10.1007/s12017-021-08663-1. Epub 2021 Apr 24.
4
Urokinase-type Plasminogen Activator Induces Neurorepair in the Ischemic Brain.尿激酶型纤溶酶原激活剂诱导缺血性脑损伤的神经修复。
J Neurol Exp Neurosci. 2018;4(2):24-29. doi: 10.17756/jnen.2018-039. Epub 2018 Sep 26.
5
A Role of Endogenous Progesterone in Stroke Cerebroprotection Revealed by the Neural-Specific Deletion of Its Intracellular Receptors.通过细胞内受体的神经特异性缺失揭示内源性孕酮在脑卒中脑保护中的作用。
J Neurosci. 2017 Nov 8;37(45):10998-11020. doi: 10.1523/JNEUROSCI.3874-16.2017. Epub 2017 Oct 6.
6
Neuronal Cell Sheets of Cortical Motor Neuron Phenotype Derived from Human iPSCs.源自人诱导多能干细胞的皮质运动神经元表型的神经细胞片。
Cell Transplant. 2017 Aug;26(8):1355-1364. doi: 10.1177/0963689717720280.
7
Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis.音猬因子在反应性星形胶质细胞增生的机械拉伸模型中刺激神经突生长。
Sci Rep. 2016 Feb 23;6:21896. doi: 10.1038/srep21896.
8
Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-β signaling.少突胶质前体细胞通过转化生长因子-β信号通路维持血脑屏障的完整性。
PLoS One. 2014 Jul 31;9(7):e103174. doi: 10.1371/journal.pone.0103174. eCollection 2014.
9
Memantine enhances recovery from stroke.美金刚可促进脑卒中康复。
Stroke. 2014 Jul;45(7):2093-2100. doi: 10.1161/STROKEAHA.113.004476. Epub 2014 Jun 17.
10
Neuronal production of lipocalin-2 as a help-me signal for glial activation.神经细胞产生脂钙素-2作为胶质细胞激活的求助信号。
Stroke. 2014 Jul;45(7):2085-92. doi: 10.1161/STROKEAHA.114.005733. Epub 2014 Jun 10.
本文引用的文献
1
MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma.MAG 和 OMgp 与 Nogo-A 协同作用，限制脊髓损伤后的轴突生长和神经恢复。
J Neurosci. 2010 May 19;30(20):6825-37. doi: 10.1523/JNEUROSCI.6239-09.2010.
2
Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling.星形细胞产生的 Ephrins 通过 VAV2 信号抑制雪旺细胞迁移。
J Neurosci. 2010 Mar 24;30(12):4246-55. doi: 10.1523/JNEUROSCI.3351-09.2010.
3
The PKB/AKT pathway in cancer.癌症中的 PKB/AKT 通路。
Curr Pharm Des. 2010 Jan;16(1):34-44. doi: 10.2174/138161210789941865.
4
Combination of NEP 1-40 treatment and motor training enhances behavioral recovery after a focal cortical infarct in rats.NEP 1-40 治疗与运动训练联合促进大鼠局灶性皮质梗死后的行为恢复。
Stroke. 2010 Mar;41(3):544-9. doi: 10.1161/STROKEAHA.109.572073. Epub 2010 Jan 14.
5
A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.大规模的化学筛选发现，调节精氨酸酶 1 启动子的物质中，大豆异黄酮染料木黄酮是一种已被临床认可的小分子，可以通过非 cAMP 依赖途径促进神经元的保护或再生。
J Neurosci. 2010 Jan 13;30(2):739-48. doi: 10.1523/JNEUROSCI.5266-09.2010.
6
Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord.Rho相关激酶II（ROCKII）限制成年小鼠脊髓创伤后的轴突生长。
J Neurosci. 2009 Dec 2;29(48):15266-76. doi: 10.1523/JNEUROSCI.4650-09.2009.
7
Promoting axonal rewiring to improve outcome after stroke.促进轴突重连以改善中风后的预后。
Neurobiol Dis. 2010 Feb;37(2):259-66. doi: 10.1016/j.nbd.2009.11.009. Epub 2009 Nov 26.
8
Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury.热稳定化 chABC 的持续递送增强了脊髓损伤后的轴突发芽和功能恢复。
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3340-5. doi: 10.1073/pnas.0905437106. Epub 2009 Nov 2.
9
Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways.Mst3b，一种 Ste20 样激酶，调节成熟中枢神经系统和周围神经系统通路中的轴突再生。
Nat Neurosci. 2009 Nov;12(11):1407-14. doi: 10.1038/nn.2414. Epub 2009 Oct 25.
10
PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.蛋白酪氨酸磷酸酶σ是硫酸软骨素蛋白聚糖的一种受体，硫酸软骨素蛋白聚糖是神经再生的一种抑制剂。
Science. 2009 Oct 23;326(5952):592-6. doi: 10.1126/science.1178310. Epub 2009 Oct 15.
Zotero 插件