Laboratoire des Substances d'Origine Naturelle et Analogues Structuraux, UPRES-EA 921, IFR 149 QUASAV, UFR des Sciences pharmaceutiques et ingénierie de la santé, Université d'Angers, Angers, France.
Molecules. 2010 Sep 16;15(9):6476-84. doi: 10.3390/molecules15096476.
Alkaloids from Thalictrum flavum L. (Ranuculaceae) growing in the Loire valley (France) were isolated and evaluated for their antiplasmodial and leishmanicidal activities. Berberine was identified as a major component but its analogue, pseudoberberine, was isolated for the first time from this plant. As far as bisbenzylisoquinolines are concerned, thalfoetidine was also isolated and, besides, its nor- derivative, northalfoetidine, was identified as a new compound. Previously isolated alkaloids from Thalictrum species such as northalidasine, northalrugosidine, thaligosidine, thalicberine, thaliglucinone, preocoteine, O-methylcassythine and armepavine were newly described in the roots of T. flavum. Tertiary isoquinolines, and particularly bisbenzylisoquinolines, were found to be leishmanicidal against L. major. Thalfoetidine appeared as the most potent but its new nor- derivative northalfoetidine, as well as northalidasine, were of particular interest due to the fact that their potential leishmanicidal activity was not associated to a strong cytotoxicity.
从法国卢瓦尔河谷生长的唐松草（毛茛科）中分离得到的生物碱，并评估其抗疟原虫和杀利什曼原虫活性。鉴定出黄连素是主要成分，但它的类似物假小檗碱是首次从这种植物中分离得到的。就双苄基异喹啉而言，唐松草定也被分离出来，此外，它的去甲衍生物，去甲唐松草定被鉴定为一种新化合物。以前从唐松草属植物中分离得到的生物碱，如北唐松草定、北唐松草定、唐松草定、唐松草定、唐松草定、唐松草定、唐松草定、唐松草定等，在唐松草的根部也有新的描述。发现叔异喹啉，特别是双苄基异喹啉，对利什曼原虫有杀利什曼原虫活性。唐松草定是最有效的，但它的新的去甲衍生物去甲唐松草定，以及北唐松草定，由于其潜在的杀利什曼原虫活性与强细胞毒性无关，因此特别有趣。
