Nagpal Anish P, Soni Harshad, Haribhakti Sanjiv
Department of Surgical Gastroenterology, Haribhakti Surgical Hospital, Ahmedabad, India.
J Minim Access Surg. 2010 Jul;6(3):66-9. doi: 10.4103/0972-9941.68581.
To evaluate retrospectively the outcome of laparoscopic fundoplication in a cohort of patients with typical symptoms of gastroesophageal reflux disease (GERD).
Forty-six patients with typical symptoms of GERD, from March 2001 to November 2009, were studied. The study was limited to patients with positive findings on upper GI endoscopy done by ourselves and "typical" symptoms (heartburn, regurgitation, and dysphagia) of GERD. Laparoscopic Nissen's fundoplication was performed when clinical assessment suggested adequate oesophageal motility and length. Only 1 patient, who had negative endoscopic findings, underwent a 24-hour pH-monitoring before surgery. Outcome measures included assessment of the relief of the primary symptom responsible for surgery in the early postoperative period; the patient's evaluation of outcome and quality of life after surgery.
Relief of the primary symptom responsible for surgery was achieved in 85% of patients at a mean follow-up of 28 months. Thirty-nine patients were asymptomatic, 2 had minor gastrointestinal symptoms not requiring medical therapy, 3 patients had gastrointestinal symptoms requiring medical therapy/ Proton Pump Inhibitors and in 2 patients the symptoms worsened after surgery. There were no deaths. Clinically significant complications occurred in 6 patients. Median hospital stay was 3 days, decreasing from 6 in the first 10 patients to 3 in the last 10 patients.
Preoperative oesophageal manometry is not mandatory for laparoscopic fundoplication done in selected patients with typical symptoms of GERD and upper GI endoscopy suggestive of large hiatus hernia.
回顾性评估一组有典型胃食管反流病(GERD)症状患者行腹腔镜胃底折叠术的疗效。
研究对象为2001年3月至2009年11月期间46例有典型GERD症状的患者。本研究仅限于经我们自己进行的上消化道内镜检查有阳性发现且有GERD“典型”症状(烧心、反流和吞咽困难)的患者。当临床评估提示食管动力和长度适宜时,行腹腔镜尼森胃底折叠术。仅1例内镜检查结果为阴性的患者在手术前行24小时pH监测。观察指标包括术后早期对导致手术的主要症状缓解情况的评估;患者对手术疗效及术后生活质量的评价。
平均随访28个月时,85%的患者导致手术的主要症状得到缓解。39例患者无症状,2例有轻微胃肠道症状但无需药物治疗,3例患者有需要药物治疗/质子泵抑制剂治疗的胃肠道症状,2例患者术后症状加重。无死亡病例。6例患者发生具有临床意义的并发症。中位住院时间为3天,从最初10例患者的6天降至最后10例患者的3天。
对于经选择的有典型GERD症状且上消化道内镜提示有大裂孔疝的患者,行腹腔镜胃底折叠术时术前食管测压并非必需。