Chen K T, Kirkegaard D D, Bocian J J
Cancer. 1980 Jul 15;46(2):368-71. doi: 10.1002/1097-0142(19800715)46:2<368::aid-cncr2820460226>3.0.co;2-e.
A case of angiosarcoma of the breast with a fatal outcome is reported, and the world literature on this rare type of breast tumor is reviewed. Familiarity with the clinical and pathologic features of this entity is essential in avoiding underdiagnosis and delay of definitive treatment. The three-year survival rate of reported cases was 38%. However, the three-year, disease-free survival was only 14%. Five cases with five-year, disease-free survival have been reported to date. Eighteen patients (21%) showed contralateral breast involvement; in half of these, it occurred before other evidence of tumor dissemination. Simple mastectomy appears to be the optimal treatment of choice, since axillary node involvement is extremely rare. The role of irradiation and chemotherapy as adjuvant therapy remains to be evaluated.
本文报告了一例致死性乳腺血管肉瘤病例，并对关于这种罕见乳腺肿瘤类型的世界文献进行了综述。熟悉该实体的临床和病理特征对于避免漏诊和延误确定性治疗至关重要。报告病例的三年生存率为38%。然而，三年无病生存率仅为14%。迄今为止，已有5例患者实现了五年无病生存。18例患者（21%）出现对侧乳腺受累；其中一半是在出现其他肿瘤播散证据之前发生的。单纯乳房切除术似乎是最佳治疗选择，因为腋窝淋巴结受累极为罕见。放疗和化疗作为辅助治疗的作用仍有待评估。
