钴胺素和类咕啉依赖性酶。
Cobalamin- and corrinoid-dependent enzymes.
作者信息
Matthews Rowena G
机构信息
Department of Biological Chemistry and Life Sciences Institute, University of Michigan, Ann Arbor MI 48109-2216, USA
出版信息
Met Ions Life Sci. 2009;6:53-114. doi: 10.1039/BK9781847559159-00053. Epub 2009 Jan 30.
Abstract
This chapter reviews the literature on cobalamin- and corrinoid-containing enzymes. These enzymes fall into two broad classes, those using methylcobalamin or related methylcorrinoids as prosthetic groups and catalyzing methyl transfer reactions, and those using adenosylcobalamin as the prosthetic group and catalyzing the generation of substrate radicals that in turn undergo rearrangements and/or eliminations.
摘要
本章回顾了有关含钴胺素和类咕啉酶的文献。这些酶大致可分为两类，一类使用甲基钴胺素或相关甲基类咕啉作为辅基并催化甲基转移反应，另一类使用腺苷钴胺素作为辅基并催化底物自由基的生成，这些自由基继而发生重排和/或消除反应。
相似文献
1
Cobalamin- and corrinoid-dependent enzymes.钴胺素和类咕啉依赖性酶。
Met Ions Life Sci. 2009;6:53-114. doi: 10.1039/BK9781847559159-00053. Epub 2009 Jan 30.
2
Cobalamin-dependent methyltransferases.钴胺素依赖性甲基转移酶
Acc Chem Res. 2001 Aug;34(8):681-9. doi: 10.1021/ar0000051.
3
Vitamin B in the spotlight again.维生素B再次成为焦点。
Curr Opin Chem Biol. 2017 Apr;37:63-70. doi: 10.1016/j.cbpa.2017.01.013. Epub 2017 Feb 3.
4
Cobalamin as coenzyme: a twisting trail of research.
Am J Hematol. 1990 Jun;34(2):83-9. doi: 10.1002/ajh.2830340203.
5
Diversity of cobalamin riboswitches in the corrinoid-producing organohalide respirer Desulfitobacterium hafniense.钴胺素核糖开关在产钴胺素有机卤呼吸菌脱硫脱硫弧菌中的多样性。
J Bacteriol. 2013 Nov;195(22):5186-95. doi: 10.1128/JB.00730-13. Epub 2013 Sep 13.
6
The inhibition of corrinoid-catalyzed oxidation of mercaptoethanol by methyl iodide: mechanistic implications.碘甲烷对类咕啉催化的巯基乙醇氧化反应的抑制作用：机理探讨
J Inorg Biochem. 1993 Apr 1;50(1):47-63. doi: 10.1016/0162-0134(93)80013-y.
7
Kinetic and spectroscopic studies of the ATP:corrinoid adenosyltransferase PduO from Lactobacillus reuteri: substrate specificity and insights into the mechanism of Co(II)corrinoid reduction.来自罗伊氏乳杆菌的ATP：类咕啉腺苷基转移酶PduO的动力学和光谱研究：底物特异性及对Co（II）类咕啉还原机制的见解
Biochemistry. 2008 Aug 26;47(34):9007-15. doi: 10.1021/bi800419e. Epub 2008 Aug 2.
8
Metagenomic and Metatranscriptomic Analyses Reveal the Structure and Dynamics of a Dechlorinating Community Containing Dehalococcoides mccartyi and Corrinoid-Providing Microorganisms under Cobalamin-Limited Conditions.宏基因组学和宏转录组学分析揭示了在钴胺素限制条件下，包含麦氏脱卤球菌和钴胺素提供微生物的脱氯群落的结构和动态。
Appl Environ Microbiol. 2017 Mar 31;83(8). doi: 10.1128/AEM.03508-16. Print 2017 Apr 15.
9
[Vitamin B12 as a biologically active model compound].[作为生物活性模型化合物的维生素B12]
Naturwissenschaften. 1982 Feb;69(2):63-74. doi: 10.1007/BF00441225.
10
O-demethylase from Acetobacterium dehalogenans--cloning, sequencing, and active expression of the gene encoding the corrinoid protein.来自脱卤产乙酸菌的O-脱甲基酶——类咕啉蛋白编码基因的克隆、测序及活性表达
Eur J Biochem. 1998 Oct 15;257(2):515-21. doi: 10.1046/j.1432-1327.1998.2570515.x.
引用本文的文献
1
Adaptive Tolerance of Listeria monocytogenes to Chemical Oxidants: Comparative Analysis of Transcriptomic Studies.单核细胞增生李斯特菌对化学氧化剂的适应性耐受：转录组学研究的比较分析
Compr Rev Food Sci Food Saf. 2025 Sep;24(5):e70260. doi: 10.1111/1541-4337.70260.
2
Impact of trace metal supplementation on anaerobic biological methanation under hydrogen and carbon dioxide starvation.微量金属添加对氢气和二氧化碳饥饿条件下厌氧生物甲烷化的影响。
NPJ Biofilms Microbiomes. 2025 Jan 8;11(1):7. doi: 10.1038/s41522-025-00649-2.
3
SignatureFinder enables sequence mining to identify cobalamin-dependent photoreceptor proteins.SignatureFinder可通过序列挖掘来识别钴胺素依赖性光感受器蛋白。
FEBS J. 2025 Feb;292(3):635-652. doi: 10.1111/febs.17377. Epub 2024 Dec 24.
4
Evidence for corrin biosynthesis in the last universal common ancestor.最后共同祖先中钴胺素生物合成的证据。
FEBS J. 2025 Feb;292(4):827-850. doi: 10.1111/febs.17367. Epub 2024 Dec 21.
5
Mechanism of Methyl Transfer Reaction between CHCo(dmgBF)py and PPhNi(Triphos).CHCo(dmgBF)py与PPhNi(Triphos)之间甲基转移反应的机理
Molecules. 2024 Jul 16;29(14):3335. doi: 10.3390/molecules29143335.
6
An Ecological Basis for Dual Genetic Code Expansion in Marine Deltaproteobacteria.海洋δ-变形菌双重遗传密码扩展的生态基础
Front Microbiol. 2021 Jul 14;12:680620. doi: 10.3389/fmicb.2021.680620. eCollection 2021.
7
Activation modes in biocatalytic radical cyclization reactions.生物催化自由基环化反应中的活化模式。
J Ind Microbiol Biotechnol. 2021 Jun 4;48(3-4). doi: 10.1093/jimb/kuab021.
8
Oxygen-Free Regioselective Biocatalytic Demethylation of Methyl-phenyl Ethers via Methyltransfer Employing Veratrol--demethylase.利用藜芦醇脱甲基酶通过甲基转移实现甲基苯基醚的无氧区域选择性生物催化脱甲基反应
ACS Catal. 2020 Sep 18;10(18):10375-10380. doi: 10.1021/acscatal.0c02790. Epub 2020 Aug 31.
9
MtcB, a member of the MttB superfamily from the human gut acetogen , is a cobalamin-dependent carnitine demethylase.MtcB 是人体肠道产乙酸菌 MttB 超家族的成员，是一种钴胺素依赖性肉碱脱甲基酶。
J Biol Chem. 2020 Aug 21;295(34):11971-11981. doi: 10.1074/jbc.RA120.012934. Epub 2020 Jun 22.
10
Catalytic effect of riboflavin on electron transfer from NADH to aquacobalamin.核黄素对烟酰胺腺嘌呤二核苷酸（NADH）向水钴胺素电子转移的催化作用。
J Biol Inorg Chem. 2020 Feb;25(1):125-133. doi: 10.1007/s00775-019-01745-3. Epub 2019 Nov 26.
本文引用的文献
1
A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor.甲硫氨酸合酶的一种二硫键稳定构象揭示了钴胺素辅因子中组氨酸配体的意外作用。
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4115-20. doi: 10.1073/pnas.0800329105. Epub 2008 Mar 10.
2
Ligand trans influence governs conformation in cobalamin-dependent methionine synthase.配体反式影响调控钴胺素依赖性甲硫氨酸合酶的构象。
Biochemistry. 2007 Oct 30;46(43):12382-92. doi: 10.1021/bi701367c. Epub 2007 Oct 9.
3
Coupling of hydrogenic tunneling to active-site motion in the hydrogen radical transfer catalyzed by a coenzyme B12-dependent mutase.在依赖辅酶B12的变位酶催化的氢自由基转移中，氢隧穿与活性位点运动的耦合。
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10774-9. doi: 10.1073/pnas.0702188104. Epub 2007 Jun 20.
4
Probing interactions from solvent-exchangeable protons and monovalent cations with the 1,2-propanediol-1-yl radical intermediate in the reaction of dioldehydrase.在二醇脱水酶反应中，通过可与溶剂交换的质子和单价阳离子探测与1,2-丙二醇-1-基自由基中间体的相互作用。
Protein Sci. 2007 Jun;16(6):1157-64. doi: 10.1110/ps.072768007.
5
Dioldehydrase: an essential role for potassium ion in the homolytic cleavage of the cobalt-carbon bond in adenosylcobalamin.二醇脱水酶：钾离子在腺苷钴胺素钴-碳键均裂中的重要作用。
Biochemistry. 2007 Jun 19;46(24):7293-301. doi: 10.1021/bi700078z. Epub 2007 May 22.
6
New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin.磷霉素生物合成过程中甲基转移机制的新见解。
Chem Commun (Camb). 2007 Jan 28(4):359-61. doi: 10.1039/b614678c. Epub 2006 Nov 23.
7
Does Cob(II)alamin act as a conductor in coenzyme B12 dependent mutases?钴胺素（II）在依赖辅酶B12的变位酶中是否充当导体？
Angew Chem Int Ed Engl. 2007;46(6):980-3. doi: 10.1002/anie.200602977.
8
Insight into the mechanism of biological methanol activation based on the crystal structure of the methanol-cobalamin methyltransferase complex.基于甲醇-钴胺素甲基转移酶复合物晶体结构对生物甲醇活化机制的洞察。
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18917-22. doi: 10.1073/pnas.0603650103. Epub 2006 Dec 1.
9
Analysis of the Cob(II)alamin-5'-deoxy-3',4'-anhydroadenosyl radical triplet spin system in the active site of diol dehydrase.二醇脱水酶活性位点中钴胺素-5'-脱氧-3',4'-脱水腺苷自由基三重态自旋体系的分析。
Biochemistry. 2006 Dec 5;45(48):14362-70. doi: 10.1021/bi061586q.
10
Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis.参与乙酰辅酶A合成的类咕啉铁硫蛋白甲基转移反应的结构解析
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14331-6. doi: 10.1073/pnas.0601420103. Epub 2006 Sep 18.
Zotero 插件