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本文引用的文献

1
A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor.甲硫氨酸合酶的一种二硫键稳定构象揭示了钴胺素辅因子中组氨酸配体的意外作用。
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4115-20. doi: 10.1073/pnas.0800329105. Epub 2008 Mar 10.
2
Ligand trans influence governs conformation in cobalamin-dependent methionine synthase.配体反式影响调控钴胺素依赖性甲硫氨酸合酶的构象。
Biochemistry. 2007 Oct 30;46(43):12382-92. doi: 10.1021/bi701367c. Epub 2007 Oct 9.
3
Coupling of hydrogenic tunneling to active-site motion in the hydrogen radical transfer catalyzed by a coenzyme B12-dependent mutase.在依赖辅酶B12的变位酶催化的氢自由基转移中，氢隧穿与活性位点运动的耦合。
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10774-9. doi: 10.1073/pnas.0702188104. Epub 2007 Jun 20.
4
Probing interactions from solvent-exchangeable protons and monovalent cations with the 1,2-propanediol-1-yl radical intermediate in the reaction of dioldehydrase.在二醇脱水酶反应中，通过可与溶剂交换的质子和单价阳离子探测与1,2-丙二醇-1-基自由基中间体的相互作用。
Protein Sci. 2007 Jun;16(6):1157-64. doi: 10.1110/ps.072768007.
5
Dioldehydrase: an essential role for potassium ion in the homolytic cleavage of the cobalt-carbon bond in adenosylcobalamin.二醇脱水酶：钾离子在腺苷钴胺素钴-碳键均裂中的重要作用。
Biochemistry. 2007 Jun 19;46(24):7293-301. doi: 10.1021/bi700078z. Epub 2007 May 22.
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New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin.磷霉素生物合成过程中甲基转移机制的新见解。
Chem Commun (Camb). 2007 Jan 28(4):359-61. doi: 10.1039/b614678c. Epub 2006 Nov 23.
7
Does Cob(II)alamin act as a conductor in coenzyme B12 dependent mutases?钴胺素（II）在依赖辅酶B12的变位酶中是否充当导体？
Angew Chem Int Ed Engl. 2007;46(6):980-3. doi: 10.1002/anie.200602977.
8
Insight into the mechanism of biological methanol activation based on the crystal structure of the methanol-cobalamin methyltransferase complex.基于甲醇-钴胺素甲基转移酶复合物晶体结构对生物甲醇活化机制的洞察。
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18917-22. doi: 10.1073/pnas.0603650103. Epub 2006 Dec 1.
9
Analysis of the Cob(II)alamin-5'-deoxy-3',4'-anhydroadenosyl radical triplet spin system in the active site of diol dehydrase.二醇脱水酶活性位点中钴胺素-5'-脱氧-3',4'-脱水腺苷自由基三重态自旋体系的分析。
Biochemistry. 2006 Dec 5;45(48):14362-70. doi: 10.1021/bi061586q.
10
Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis.参与乙酰辅酶A合成的类咕啉铁硫蛋白甲基转移反应的结构解析
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14331-6. doi: 10.1073/pnas.0601420103. Epub 2006 Sep 18.

钴胺素和类咕啉依赖性酶。

Cobalamin- and corrinoid-dependent enzymes.

作者信息

Matthews Rowena G

机构信息

Department of Biological Chemistry and Life Sciences Institute, University of Michigan, Ann Arbor MI 48109-2216, USA

出版信息

Met Ions Life Sci. 2009;6:53-114. doi: 10.1039/BK9781847559159-00053. Epub 2009 Jan 30.

DOI:10.1039/BK9781847559159-00053
PMID:20877792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3120101/
Abstract

This chapter reviews the literature on cobalamin- and corrinoid-containing enzymes. These enzymes fall into two broad classes, those using methylcobalamin or related methylcorrinoids as prosthetic groups and catalyzing methyl transfer reactions, and those using adenosylcobalamin as the prosthetic group and catalyzing the generation of substrate radicals that in turn undergo rearrangements and/or eliminations.

摘要

本章回顾了有关含钴胺素和类咕啉酶的文献。这些酶大致可分为两类，一类使用甲基钴胺素或相关甲基类咕啉作为辅基并催化甲基转移反应，另一类使用腺苷钴胺素作为辅基并催化底物自由基的生成，这些自由基继而发生重排和/或消除反应。