Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, P.za della Scienza 2, 20126, Milano, Italy.
Nanoscale. 2011 Feb;3(2):387-90. doi: 10.1039/c0nr00436g. Epub 2010 Sep 29.
We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also assessed.
我们提出了曲妥珠单抗功能化聚乙二醇氧化铁纳米粒子的合成方法，并提供了一种基于傅里叶变换红外光谱（FTIR）的方法来直接证明结合抗体的天然结构的实际保留情况。还评估了它们对特定癌细胞受体的靶向选择性。
