辣椒素对大鼠随意型皮瓣存活能力的影响

Capsaicin on the viability of random-pattern skin flaps in rats.

作者信息

Godoy Gustavo Roberto de, Liebano Richard Eloin, Corrêa Juliana Barbosa, Hochman Bernardo, Ferreira Lydia Masako

机构信息

Plastic Surgery Division, UNIFESP, Sao Paulo, Brazil.

出版信息

Acta Cir Bras. 2010 Oct;25(5):440-3. doi: 10.1590/s0102-86502010000500010.

DOI:10.1590/s0102-86502010000500010

PMID:20877955

Abstract

PURPOSE

To evaluate the effects of capsaicin on the viability of ischemic random-pattern skin flaps in rats.

METHODS

Forty EPM1-Wistar rats were randomized into two groups of 20 animals each, the capsaicin group and the control group. A random-pattern skin flap measuring 10 x 4 cm was raised and a plastic barrier was placed between the flap and the donor site. After the surgical procedure, the control group was treated with an inert vehicle in the form of a cream applied uniformly to a rayon bandage which, in turn, was applied to the surface of the skin flap. The capsaicin group was treated in the same way, but in this case capsaicin was added to the cream. This procedure was repeated for two consecutive days.

RESULTS

There was a significantly smaller amount of flap necrosis in the capsaicin group (35.07%) than in the control group (44.75%) (p=0.035).

CONCLUSION

Topical administration of capsaicin improved the viability of ischemic random-pattern skin flaps in rats.

摘要

目的

评估辣椒素对大鼠缺血随意型皮瓣存活能力的影响。

方法

将40只EPM1-Wistar大鼠随机分为两组，每组20只，即辣椒素组和对照组。掀起一个10×4厘米的随意型皮瓣，并在皮瓣与供区之间放置一个塑料屏障。手术后，对照组用惰性载体治疗，以乳膏形式均匀涂抹在人造纤维绷带上，然后将绷带应用于皮瓣表面。辣椒素组以相同方式治疗，但在乳膏中添加了辣椒素。此过程连续重复两天。