Departamento de Nutrição, Universidade Federal de Alfenas, Unifal-MG, Alfenas, MG, Brazil.
Plant Foods Hum Nutr. 2010 Dec;65(4):319-25. doi: 10.1007/s11130-010-0191-3.
Brazilian savanna constitutes a valuable ecoregion that contributes to the supply of fruit known worldwide for its nutritional value and peculiar flavors. Among them, the Marolo (Annona crassiflora Mart.) fruit is known for its use in folk medicine. In order to establish the safety of Marolo for human consumption, this study evaluated the following: the chemical composition of Marolo pulp; its mutagenic and antimutagenic activities using micronucleus test; and the oxidative stress induced in the livers of mice fed a diet containing 1%, 10% or 20% pulp. It was observed that the chemical composition of marolo pulp was similar to that of common fruit; nevertheless, its lipidic content and energetic values were higher. In the mice fed experimental diets, the biochemical parameters of the blood serum showed normal levels of glucose, triglycerides, and cholesterol. The micronucleus test indicated neither mutagenic nor antimutagenic effects of Marolo consumption on bone marrow cells but showed potentialization of cyclophosphamide (CP). The oxidative stress levels observed indicated that CP was not exerting a great influence on the induction of reactive oxygen species. As the whole fruit is a complex matrix, the interactions between its components could be responsible for its negative and positive biological effects.
巴西稀树草原是一个有价值的生态区，为全球提供了具有营养价值和独特风味的水果。其中，马罗洛果（Annona crassiflora Mart.）因其在民间医学中的用途而闻名。为了确定马罗洛果供人类食用的安全性，本研究评估了以下内容：马罗洛果肉的化学成分；使用微核试验评估其致突变和抗突变活性；以及喂食含有 1%、10%或 20%果肉的饮食对小鼠肝脏诱导的氧化应激。结果表明，马罗洛果肉的化学成分与常见水果相似，但脂质含量和能量值更高。在喂食实验饮食的小鼠中，血清生化参数显示葡萄糖、甘油三酯和胆固醇水平正常。微核试验表明，马罗洛果的摄入对骨髓细胞既没有致突变作用，也没有抗突变作用，但对环磷酰胺（CP）有潜在作用。观察到的氧化应激水平表明，CP 对诱导活性氧的产生没有很大影响。由于整个水果是一个复杂的基质，其成分之间的相互作用可能是其产生负面和正面生物学效应的原因。
