胆汁淤积性肝病中的载脂蛋白A-1
Apolipoprotein A-1 in cholestatic liver diseases.
作者信息
Yamamoto K, Koga S, Ibayashi H
出版信息
Clin Chim Acta. 1978 Jul 1;87(1):85-92. doi: 10.1016/0009-8981(78)90061-x.
PMID:208804
Abstract
The apolipoprotein A-1 in cholestatic liver diseases was determined by rocket immunoelectrophoresis. A decrease in the serum apo A-1 was generally observed in LP-X positive liver disease, particularly in the patients with extrahepatic biliary obstruction. With reference to LP-X levels and LCAT activity, the results indicated that not only hepatocellular damage but also cholestasis contribute to the decrease of apo A-1 concentration in patients with liver disease.
摘要
采用火箭免疫电泳法测定胆汁淤积性肝病患者的载脂蛋白A-1。一般在LP-X阳性肝病患者中观察到血清载脂蛋白A-1降低，尤其是肝外胆管梗阻患者。结合LP-X水平和卵磷脂胆固醇酰基转移酶活性，结果表明，肝病患者载脂蛋白A-1浓度降低不仅与肝细胞损伤有关，还与胆汁淤积有关。
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