血脂谱和月经周期与寻常痤疮的关系。
The relationship of lipid profile and menstrual cycle with acne vulgaris.
机构信息
Department of Biochemistry, Pt B D Sharma, UHS, Rohtak, Haryana, India.
出版信息
Clin Biochem. 2010 Dec;43(18):1415-20. doi: 10.1016/j.clinbiochem.2010.09.010. Epub 2010 Sep 27.
OBJECTIVE
The aim of this study was to find lipid profile and hormone levels in patients with severe acne vulgaris and to correlate lipid profile with hormone levels.
DESIGN AND METHODS
Prospective study was performed in the 60 patients of severe acne vulgaris. Lipid profile and serum testosterone, estrogen, and progesterone levels were measured in three consecutive menstrual cycles during luteal phase (19th to 21st day). Their results were compared with a group of 60 age-matched healthy controls.
RESULTS
Total cholesterol (TC), LDL-C, testosterone, and progesterone levels were higher in patients. Estrogen and HDL-C levels were decreased in patients. Positive correlation was found between testosterone and TC and LDL-C. Estrogen levels were positively correlated with VLDL-C, triglyceride levels, and HDL-C and negatively correlated with TC and LDL-C.
CONCLUSIONS
These abnormalities must be considered in the pathogenesis of the disease and must be taken into account for the treatment of patients of acne.
目的
本研究旨在探讨寻常痤疮患者的血脂谱和激素水平，并分析血脂谱与激素水平的相关性。
设计与方法
对 60 例寻常痤疮患者进行前瞻性研究。在黄体期（第 19-21 天）连续三个月经周期内测量血脂谱和血清睾酮、雌二醇和孕酮水平，并与 60 例年龄匹配的健康对照组进行比较。
结果
患者的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、睾酮和孕酮水平较高，而雌二醇和高密度脂蛋白胆固醇（HDL-C）水平较低。睾酮与 TC 和 LDL-C 呈正相关，雌二醇与 VLDL-C、甘油三酯水平和 HDL-C 呈正相关，与 TC 和 LDL-C 呈负相关。
结论
这些异常在疾病的发病机制中必须得到考虑，并应考虑用于寻常痤疮患者的治疗。
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