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情境因素在双相情感障碍患者功能中的作用和影响。

The role and impact of contextual factors on functioning in patients with bipolar disorder.

机构信息

Instituto de Salud Carlos III, Centro de Investigacion en Red de Salud Mental, CIBERSAM, Madrid, Spain.

出版信息

Disabil Rehabil. 2010;32 Suppl 1:S94-S104. doi: 10.3109/09638288.2010.520810. Epub 2010 Oct 1.

Abstract

PURPOSES

The International Classification of Functioning, Disability and Health, provides the framework to describe individual's functioning and allows the study of the interaction between patient's health status and the environmental factors involved. The main aim of this study was to analyse systematically those factors involved in the functioning of bipolar patients including the role of contextual factors.

METHODS

Eighty-eight euthymic patients with a diagnosis of bipolar disorder were included. To examine the importance of contextual factors above and over clinical variables after controlling of potential socio-demographic variables, a hierarchical multiple regression was used.

RESULTS

Clinical variables that significantly predicted patient functioning were the total number of episodes, number of depressive episodes, family history of psychiatric disorders and mild subdepressive symptoms, accounting for 34.1% of the variance of functioning (F=2.14, p =0.011). Contextual factors, including dysfunctional attitudes and perceived social support, accounted for 17.5% of the variance (F=3.04, p <0.001).

CONCLUSIONS

Contextual factors appear to play a significant role in explaining bipolar patients' functioning after controlling for socio-demographic and clinical factors. These findings suggest that psychosocial interventions might be helpful to reduce or prevent disability associated to bipolar disorder. From an ICF model, understanding those factors may be useful to produce policy recommendations and guidelines.

摘要

目的

《国际功能、残疾和健康分类》为描述个体功能提供了框架,并允许研究患者健康状况与所涉及环境因素之间的相互作用。本研究的主要目的是系统分析双相情感障碍患者的功能相关因素,包括情境因素的作用。

方法

共纳入 88 例病情稳定的双相情感障碍患者。为了在控制潜在社会人口统计学变量后,检验情境因素比临床变量更重要的作用,我们采用了分层多元回归分析。

结果

临床变量,包括发作总次数、抑郁发作次数、精神障碍家族史和轻度亚抑郁症状,显著预测了患者的功能,解释了功能变异性的 34.1%(F=2.14,p=0.011)。情境因素,包括功能失调的态度和感知到的社会支持,解释了 17.5%的变异性(F=3.04,p<0.001)。

结论

在控制社会人口统计学和临床因素后,情境因素似乎在解释双相情感障碍患者的功能方面起着重要作用。这些发现表明,心理社会干预可能有助于减少或预防与双相情感障碍相关的残疾。从国际功能、残疾和健康分类的角度来看,理解这些因素可能有助于制定政策建议和指南。

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