Department of Clinical Immunology, Transplantation Institute, Warsaw Medical University, Warsaw, Poland.
Viral Immunol. 2010 Oct;23(5):541-4. doi: 10.1089/vim.2010.0001.
Bacteriophages (viruses of bacteria) are currently considered a promising means of treating antibiotic-resistant infections. The main objective of this study was to evaluate the intensity of the whole-blood monocyte and neutrophil respiratory burst induced by purified preparations and lysates of the bacteriophages T4 and A3/R. While A3/R phage preparations did not induce a significant respiratory burst, T4 phage preparations increased the production of reactive oxygen species in a dose-dependent manner. However, the intensity of the phage-induced respiratory burst was much lower than that triggered by heat-inactivated Staphylococcus aureus cells. These results suggest that phage preparations are not likely to induce oxidative stress following their administration to patients.
噬菌体（细菌病毒）目前被认为是治疗抗生素耐药性感染的一种有前途的手段。本研究的主要目的是评估纯化制剂和噬菌体 T4 和 A3/R 的裂解物诱导全血单核细胞和中性粒细胞呼吸爆发的强度。虽然 A3/R 噬菌体制剂不会引起明显的呼吸爆发，但 T4 噬菌体制剂会以剂量依赖的方式增加活性氧的产生。然而，噬菌体诱导的呼吸爆发的强度远低于热灭活金黄色葡萄球菌细胞引发的呼吸爆发的强度。这些结果表明，噬菌体制剂在给予患者后不太可能引起氧化应激。
