Jończyk-Matysiak Ewa, Weber-Dąbrowska Beata, Owczarek Barbara, Międzybrodzki Ryszard, Łusiak-Szelachowska Marzanna, Łodej Norbert, Górski Andrzej
Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, Poland.
Phage Therapy Unit, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, Poland.
Viruses. 2017 Jun 14;9(6):150. doi: 10.3390/v9060150.
Phagocytes are the main component of innate immunity. They remove pathogens and particles from organisms using their bactericidal tools in the form of both reactive oxygen species and degrading enzymes-contained in granules-that are potentially toxic proteins. Therefore, it is important to investigate the possible interactions between phages and immune cells and avoid any phage side effects on them. Recent progress in knowledge concerning the influence of phages on phagocytes is also important as such interactions may shape the immune response. In this review we have summarized the current knowledge on phage interactions with phagocytes described so far and their potential implications for phage therapy The data suggesting that phage do not downregulate important phagocyte functions are especially relevant for the concept of phage therapy.
吞噬细胞是固有免疫的主要组成部分。它们利用杀菌工具，即活性氧和包含在颗粒中的降解酶（这些酶是潜在的有毒蛋白质），从生物体中清除病原体和颗粒。因此，研究噬菌体与免疫细胞之间可能的相互作用，并避免噬菌体对它们产生任何副作用，是很重要的。关于噬菌体对吞噬细胞影响的知识的最新进展也很重要，因为这种相互作用可能会影响免疫反应。在这篇综述中，我们总结了目前关于噬菌体与吞噬细胞相互作用的已知信息及其对噬菌体治疗的潜在影响。表明噬菌体不会下调重要吞噬细胞功能的数据与噬菌体治疗的概念特别相关。
