1 Laboratory of Bacteriophages, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, Poland.
2 Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, 02-006 Warsaw, Poland.
Exp Biol Med (Maywood). 2018 Mar;243(6):534-537. doi: 10.1177/1535370218755658. Epub 2018 Jan 23.
Allergic disorders pose a growing challenge to medicine and our society. Therefore, novel approaches to prevention and therapy are needed. Recent progress in studies on bacterial viruses (phages) has provided new data indicating that they have significant immunomodulating activities. We show how those activities could be translated into beneficial effects in allergic disorders and present initial clinical data that support this hope. Impact statement Allergic disorders pose a growing challenge to medicine and our society, so new approaches to prevention and therapy are urgently needed. Our article summarizes progress that has been recently made and presents a shift in our understanding of the immunobiological significance of bacterial viruses (phages). Currently, phages may be considered not only as mere "bacteria eaters" but also as regulators of immunity. The new understanding of phages as important factors in maintenance of immune homeostasis opens completely new perspectives for their use in controlling aberrant immune responses. It is likely that this new knowledge could be translated into novel means of immunotherapy of allergic disorders.
过敏症对医学和我们的社会构成越来越大的挑战。因此，需要新的预防和治疗方法。最近在研究细菌病毒（噬菌体）方面取得的进展提供了新的数据，表明它们具有显著的免疫调节活性。我们展示了这些活性如何转化为过敏症的有益效果，并提供了支持这一希望的初步临床数据。
影响说明
过敏症对医学和我们的社会构成越来越大的挑战，因此急需新的预防和治疗方法。我们的文章总结了最近取得的进展，并提出了对细菌病毒（噬菌体）免疫生物学意义的理解的转变。目前，噬菌体不仅可以被视为“细菌吞噬者”，还可以被视为免疫调节剂。将噬菌体理解为维持免疫稳态的重要因素，为其在控制异常免疫反应方面的应用开辟了全新的视角。很可能，这一新知识可以转化为治疗过敏症的新免疫疗法手段。
