哮喘和 COPD 重叠：两种疾病的交汇点。
Overlap Between Asthma and COPD: Where the Two Diseases Converge.
机构信息
Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
出版信息
Allergy Asthma Immunol Res. 2010 Oct;2(4):209-14. doi: 10.4168/aair.2010.2.4.209. Epub 2010 Sep 13.
Abstract
Asthma and chronic obstructive pulmonary disease (COPD) are traditionally recognized as distinct diseases, with some clearly separate characteristic. Asthma originates in childhood, is associated with allergies and eosinophils, and is best treated by targeting inflammation, whereas COPD occurs in adults who smoke, involves neutrophils, and is best treated with bronchodilators and the removal of risk factors. However, the distinction between the two is not always clear. Patients with severe asthma may present with fixed airway obstruction, and patients with COPD may have hyperresponsiveness and eosinophilia. Recognizing and understanding these overlapping features may offer new insight into the mechanisms and treatment of chronic airway inflammatory diseases.
摘要
哮喘和慢性阻塞性肺疾病（COPD）传统上被认为是两种截然不同的疾病，它们具有一些明显不同的特征。哮喘起源于儿童时期，与过敏和嗜酸性粒细胞有关，最好通过靶向炎症来治疗，而 COPD 则发生在吸烟的成年人中，涉及中性粒细胞，最好通过支气管扩张剂和消除危险因素来治疗。然而，两者之间的区别并不总是很清楚。严重哮喘患者可能表现为气道固定阻塞，而 COPD 患者可能存在高反应性和嗜酸性粒细胞增多。认识和理解这些重叠特征可能为慢性气道炎症性疾病的机制和治疗提供新的见解。
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