比较 ART 周期中冷冻胚胎移植和新鲜胚胎移植的早期妊娠和新生儿结局。
Comparison of early pregnancy and neonatal outcomes after frozen and fresh embryo transfer in ART cycles.
机构信息
Research and Clinical center for Infertility, Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Science, Bouali Ave, Safaieh, 8916877391 Yazd, Iran.
出版信息
J Assist Reprod Genet. 2010 Dec;27(12):695-700. doi: 10.1007/s10815-010-9470-z. Epub 2010 Oct 1.
Abstract
PURPOSE
frozen embryo transfer (FET) has no clear negative impact on neonatal outcome compared with fresh embryo transfer (ET) and appears to result in similar or even better neonatal outcome. The objective of this study was to compare early pregnancy outcome and neonatal health of children born after FET and fresh ET.
METHODS
in this study early pregnancy and neonatal outcomes after FET (n = 200) and fresh ET (n = 500) were compared.
RESULTS
for early pregnancy, biochemical pregnancy was comparable between FET and fresh ET groups. Spontaneous abortion was significantly higher in FET (14.5%) than fresh ET group (9%). Neonatal outcome was comparable between both groups except for lower live birth rate in FET (55%) versus fresh ET group (66%).
CONCLUSION
FET has similar neonatal outcome in terms of prematurity, low birth weight, stillbirth, neonatal death and major malformation compared with fresh ET.
摘要
目的
与新鲜胚胎移植（ET）相比，冷冻胚胎移植（FET）对新生儿结局没有明显的负面影响，并且似乎导致相似甚至更好的新生儿结局。本研究的目的是比较 FET 和新鲜 ET 后出生的儿童的早期妊娠结局和新生儿健康。
方法
本研究比较了 FET（n=200）和新鲜 ET（n=500）后的早期妊娠和新生儿结局。
结果
在早期妊娠方面，FET 和新鲜 ET 组的生化妊娠率相当。FET 组（14.5%）的自然流产率明显高于新鲜 ET 组（9%）。除 FET 组（55%）的活产率低于新鲜 ET 组（66%）外，两组新生儿结局相当。
结论
FET 在早产、低出生体重、死产、新生儿死亡和重大畸形方面与新鲜 ET 的新生儿结局相似。
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