Silverstone B Z
Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem, Israel.
Ciba Found Symp. 1990;155:210-7; discussion 217-21. doi: 10.1002/9780470514023.ch12.
There is considerable evidence supporting a link between abnormalities in zinc and copper metabolism and some disorders of the retinal pigment epithelium. Anatomical studies in highly myopic eyes show important changes in this retinal layer. We measured the blood concentrations of zinc and copper and the urine concentration of copper in different groups of highly myopic patients from Caucasian and African populations, and in highly myopic patients with retinal detachment. In the Caucasian myopic groups, many patients showed high levels of zinc and low levels of copper in serum. In the high myopic group with retinal detachment, serum zinc and copper concentrations were significantly elevated. The importance of our findings and their connection to the retinal pigment epithelium is discussed.
有大量证据支持锌和铜代谢异常与视网膜色素上皮的某些疾病之间存在联系。对高度近视眼睛的解剖学研究表明，这一视网膜层存在重要变化。我们测量了来自白种人和非洲人群的不同高度近视患者组以及视网膜脱离的高度近视患者的血液中锌和铜的浓度以及尿液中铜的浓度。在白种人近视组中，许多患者血清锌水平高而铜水平低。在伴有视网膜脱离的高度近视组中，血清锌和铜浓度显著升高。本文讨论了我们研究结果的重要性及其与视网膜色素上皮的联系。
