Silverstone B Z, Syrkin N, Algur N, Berson D
Ann Ophthalmol. 1985 Sep;17(9):546-51.
Abnormal zinc and copper metabolism has been described in some retinal disorders affecting the retinal pigment epithelium. Anatomic studies in high myopic eyes, show important changes in this retinal layer. We examined the blood for zinc and copper and urine for copper in different groups of high myopic black and white patients, and high myopic white patients with primary retinal detachment. In the white myopic groups, many of the patients showed high serum zinc and low serum copper values. In the high myopic patients with primary retinal detachment, the serum zinc and copper were found to be distinctly elevated and of statistical significance. A relative inverse copper/zinc ratio between the concentration of these metals in serum and their concentration in the subretinal fluid was noted as well. The significance of these findings and their connection to the retinal pigment epithelium is discussed.
在一些影响视网膜色素上皮的视网膜疾病中，已发现锌和铜代谢异常。对高度近视眼睛的解剖学研究表明，该视网膜层存在重要变化。我们检测了不同组别的高度近视黑人和白人患者以及患有原发性视网膜脱离的高度近视白人患者的血液锌和铜含量以及尿液铜含量。在白人近视组中，许多患者血清锌含量高而血清铜含量低。在患有原发性视网膜脱离的高度近视患者中，血清锌和铜明显升高且具有统计学意义。还注意到血清中这些金属浓度与视网膜下液中浓度之间相对的铜/锌反比关系。本文讨论了这些发现的意义及其与视网膜色素上皮的联系。
