Silverstone B Z, Seelenfreund M H, Ronen S, Kristol L, Algur N, Berson D
Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem, Israel.
Metab Pediatr Syst Ophthalmol (1985). 1988;11(3):122-5.
Abnormal zinc and copper metabolism have been described in several retinal disorders affecting the retinal pigment epithelium. An infrequent presentation of senile macular degeneration in high myopia is well known. We examined the blood for zinc and copper and the urine for copper of three groups of patients, one consisting of high myopia, another with high myopia and primary retinal detachment and the other a group of patients with senile macular degeneration. When comparing the above groups of patients, we found statistically elevated values of serum zinc (p = less than 0.005) in the group of patients with senile macular degeneration. The significance of these findings, and a correlation with the pathogeneses of high myopia and senile macular degeneration is discussed.
在几种影响视网膜色素上皮的视网膜疾病中，已发现锌和铜代谢异常。高度近视中老年黄斑变性的罕见表现是众所周知的。我们检测了三组患者的血液锌和铜水平以及尿液铜水平，一组为高度近视患者，另一组为高度近视合并原发性视网膜脱离患者，还有一组为老年黄斑变性患者。在比较上述几组患者时，我们发现老年黄斑变性患者组的血清锌值在统计学上有所升高（p＜0.005）。本文讨论了这些发现的意义以及与高度近视和老年黄斑变性发病机制的相关性。
